Med Chem 2004, 47:2430–2440.CrossRef 8. Kogan NM, Rabinowitz R, Levi P, Gibson P, Sandor D, Schlesinger M: Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. Med Chem 2004, 47:3800–3806.CrossRef 9. Kogan NM, Blázquez C, Álvarez L, Gallily R, Schlesinger M, Guzmán M, Mechoulam R: A cannabinoid quinone inhibits angiogenesis by targeting AZD1208 price vascular endothelial cells. Mol Pharm 2006, 70:51–59. 10. Kogan NM, Schlesinger M, Priel E, Rabinowitz R, Berenshtein E, Chevion M, Mechoulam R: HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor. Mol Cancer Ther 2007, 6:6173–6183.CrossRef 11. Kogan NM, Schlesinger M, Peters M, Marincheva G, Beeri R, Mechoulam R: A cannabinoid anticancer quinone,
HU-331, is more potent and less cardiotoxic than doxorubicin: a comparative in vivo study. JPET 2007, 322:646–653.CrossRef 12. Filosa R, Peduto A, De Caprariis P, Saturnino C, Festa M, Petrella A, Pau A, Pinna GA, La Colla P, Busonera B, Loddo R: Synthesis and antiproliferative properties of N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine. Tanespimycin research buy MedChem 2007, 42:293–306. 13. Filosa R, Peduto
A, Micco SD, Caprariis P, Festa M, Petrella A, Capranico G, Bifulco G: Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors. MedChem 2009, 17:13–24. 14. Peduto A, Pagano B, Petronzi C, Massa A, Esposito V, Virgilio A, Paduano F, Trapasso F, Fiorito F, Florio S, Giancola G, Filosa R: Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands. BioorgMedChem. 2011, 21:6419–6429. 15. Petronzi C, Filosa R, Peduto A, Monti MC, Margarucci L, Massa A: Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues. Eur J Med Chem 2011, 46:488–496.PubMedCrossRef
16. Pengfei Z, Yanxia N, Liangqing Y, Mo C, Congjian X: The proliferation, apoptosis, invasion of endothelial-like 17-DMAG (Alvespimycin) HCl epithelial ovarian cancer cells induced by hypoxia. J Exp Clin Cancer Res 2010, 29:124.CrossRef 17. Deveraux QL, Reed JC: IAP family proteins–suppressors of apoptosis. Genes Dev 1999, 1:239–252.CrossRef 18. Riccardi C, Nicoletti I: Analysis of apoptosis by propidium iodide staining and flow cytometry. NatProt 2006, 1:1458–1461. 19. Caraglia M, Leardi A, Corradino S, Ciardiello F, Budillon A, Guarrasi R, Bianco AR, Tagliaferri P: Alpha-Interferon potentiates epidermal growth factor receptor-mediated effects on human epidermoid carcinoma KB cells. Int J Cancer 1995, 61:342–347.PubMedCrossRef 20. Xiao-Fen L, Cong-Xiang S, Zhong Wen Yu-Hong Q, Chao-Sheng Y, Jun-Qi W, Ping-Neng Z, Hai-Li W: PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells. J Exp Clin Cancer Res 2012, 31:12.CrossRef 21.