Toxicol Lett 2009, 189:177–183.CrossRef 21. Xie G, Sun J, Zhong G, Shi L, Zhang D: Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Arch Toxicol 2010, 84:183–190.CrossRef 22. Huang X, Li L, Liu T, Hao N, Liu H, Chen D, Tang F: The shape effect of mesoporous silica nanoparticles on biodistribution, clearance,
and biocompatibility in vivo. ACS Nano 2011, 5:5390–5399.CrossRef 23. Liu T, Li L, Fu C, Liu H, Chen D, Tang F: Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles. Biomaterials 2012, 33:2399–2407.CrossRef 24. Yu T, Hubbard D, Ray A, Ghandehari H: In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface this website characteristics. J selleck screening library Control Release 2012, 163:46–54.CrossRef 25. Fede C, Selvestrel F, Compagnin C, Mognato M, Mancin F, Reddi E, Celotti L: The toxicity outcome
of silica nanoparticles (Ludox®) is influenced VX-689 nmr by testing techniques and treatment modalities. Anal Bioanal Chem 2012, 404:6–7.CrossRef 26. Wang F, Gao F, Lan M, Yuan H, Huang Y, Liu J: Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells. Toxicol In Vitro 2009, 23:808–815.CrossRef 27. Park E, Park K: Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 2009, 184:18–25.CrossRef 28. Bhattacharjee Niclosamide S, de Haan L, Evers N, Jiang X, Marcelis A, Zuilhof H, Rietjens I, Alink G: Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells. Particle and
Fibre Toxicology 2010, 7:25.CrossRef 29. D’Autréaux B, Toledano MB: ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Bio 2007, 8:813–824.CrossRef 30. Sies H: Oxidative stress: Introduction. In Oxidative Stress: Oxidants and Antioxidants. Edited by: Sies H. San Diego: Academic Press; 1991:15–22. 31. Marks D, Marks A, Smith C: Oxygen metabolism and toxicity. In Basic Medical Biochemistry: A Clinical Approach. Edited by: Williams W. Baltimore: Lippincott Williams and Wilkins; 1996:327–340. 32. Lushchak V: Environmentally induced oxidative stress in aquatic animals. Aquat Toxicol 2011,101(1):13–30.CrossRef 33. Kelly KA, Havrilla CM, Brady TC, Abramo KH, Levin ED: Oxidative stress in toxicology: established mammalian and emerging piscine model systems. Environ Health Perspect 1998, 106:375–384.CrossRef 34. Wilhelm-Filho D: Reactive oxygen species, antioxidants and fish mitochondria. Front Biosci 2007, 12:1229–1237.CrossRef 35. Hermez-Lima M: Oxygen in biology and biochemistry: role of free radicals. In Functional Metabolism: Regulation and Adaptation. Edited by: Storey K. Hoboken: Wiley; 2004:319–368. 36.