fascicularis). Two tests are bimanual coordinated tasks: the bimanual Brinkman board task (Mark and Sperry 1968) and the tube task (Hopkins 1995), whereas the third test is the modified Brinkman board task (original test: Brinkman and Kuypers 1973; see also Brinkman 1984), performed either unimanually or with both hands at the same time. Monkeys had to perform an additional task, the reach and grasp drawer task, whereas humans had to answer a handedness questionnaire, which allowed us to confirm the self-assessment of each subject and,

then, to compare the self-assessment with Inhibitors,research,lifescience,medical the results derived from the manual dexterity tests. More specifically, the aim of the study was to test the hypothesis that, in M. fascicularis, hand preference is variable across tasks and individuals, the dominant hand does not systematically correspond to the preferred hand, whereas human subjects exhibit more systematic lateralization (hand preference) Inhibitors,research,lifescience,medical and the preferred hand generally corresponds to the most dexterous hand (dominant hand). BIIB057 price Material and Methods Nonhuman primate subjects The experiments were conducted on eight adult female monkeys (M. fascicularis), aged between 6 and 7 years old at the beginning of the tests (weight: 3–3.9 kg) and housed in 45 m3 rooms with four other animals. The monkeys were neither food nor water deprived (see e.g., Kaeser et al. 2010; Schmidlin et al. 2011). None Inhibitors,research,lifescience,medical of the animals

had executed the different manual dexterity tasks before, so they were totally naïve.

The experimental protocol has been approved by the local ethical committee on animal experimentation and it was in accordance with the Guidelines for the Care and Use of Laboratory Animals (ISBN 0-309-05377-3; Inhibitors,research,lifescience,medical 1996), as well as authorized by local (Canton of Fribourg) and federal (Swiss) veterinary authorities. The present experiments were covered by the official authorization numbers FR 192/07E, FR 206/08, FR 17/09, FR 18/10, FR 22010. The experimental procedures were designed to minimize pain and suffering for the animals. In the part of the present study on monkeys, the Inhibitors,research,lifescience,medical protocol was restricted to behavioral assessment, without any surgical or pharmacological intervention. The macaque monkeys originate initially from an officially recognized breeding center in China and were imported via a quarantine center in Europe (Harlan, Milano, Italy), where they stayed during a few months within a large group of a couple of dozen animals Nature Chemical Biology from the same origin. After arrival in our animal facility, the animals were habituated during 1–2 months to the new environment, before starting the habituation procedure (2–3 months duration) aimed at transferring the monkey on a free-will basis to the primate chair (see Schmidlin et al. 2011). The present behavioral experiments were then initiated when the monkeys were comfortable with the primate chair. During each behavioral test, the monkey sat in a primate chair (see Schmidlin et al.