On the other hand, antibody levels may rise after an Angiogenesis inhibitor asymptomatic infection in vaccinated individuals.2 The WHO reports 98 proven cases of pertussis from Iran in 2004, and 125 cases in 2005.1 These figures have grossly underestimated the true numbers and result from under-diagnosis and under-reporting, both of which stem from a lack of definite clinical diagnostic criteria and appropriate laboratory methods. Our figures vary widely from those of Ghanaie and colleagues from Iran who

quote an incidence of 318/100000 in 2008 in Tehran among school children between the ages of 6-14 years.20 This disparity could be explained by the differences in the age of Inhibitors,research,lifescience,medical the study population in the 2 studies as well as the use of different criteria used for the diagnosis of pertussis; theirs being clinical manifestation plus a positive PCR. Conclusion Inhibitors,research,lifescience,medical A considerable percentage of children had high levels of anti-pertussis

IgG antibodies, positive anti-pertussis IgA, and most importantly a significant rise of anti-pertussis IgG GMT at 6 years of age, depicting a natural infection in vaccinated children. Further surveys need to be done to study the medium and long-term Inhibitors,research,lifescience,medical protection afforded by the current vaccine, in order to prevent the disease in these age group. Acknowledgment We would like to thank the Health Inhibitors,research,lifescience,medical Policy Research Center affiliated to Shiraz University of Medical Sciences and the Pediatric Infections Research Center affiliated to Shahid Beheshti University

of Medical Sciences for their financial support. Conflict of Interest: None declared
Background: The areas of the bed nucleus of the stria terminalis (BST) with a high density of estrogen receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (RVLM). We aimed to Inhibitors,research,lifescience,medical find the contribution of the RVLM to cardiovascular responses elicited by glutamate microinjection into the BST. Methods: Experiments were done in α-chloralose anesthetized ovariectomized (OVX) or OVX estrogen treated (OVX+E) female Wistar rats. Drugs were microinjected into the BST and RVLM. The average changes in mean arterial pressure (MAP) and heart rate (HR) were compared between the case and control groups using t test and with the pre-injection values using paired t test. Results: Unilateral microinjection of glutamate (0.25 M/50 nl) through into the BST decreased MAP and HR, in the OVX+E and OVX rats. These cardiovascular responses were reversibly attenuated 10 minutes after microinjection of synaptic blocker cobalt chloride (CoCl2, 5 mM/50 nl) into the ipsilateral RVLM. Re-stimulation of the BST 60 min after CoCl2 injection elicited cardiovascular responses that were not different from the control values. Ipsilateral microinjection of GABAA antagonist bicuculline (1.