It is unclear if these infants receive the subsequent 3 doses of hepatitis B vaccine or have confirmed hepatitis B immunity as follow-up was by primary care physician. 11,362 (95%) infants received the birth dose of HB vaccine prior to discharge from hospital. Of 28 HBsAg positive women, 11 were seen in our gastroenterology department by either a hepatology nurse or a gastroenterologist, and only 7 were seen during a pregnancy. Conclusion: Although we have a low prevalence and excellent screening and immuno-prophylaxis rates, our current practices do not adequately identify

high risk patients and would not facilitate maternal treatment in late pregnancy. New local policies should be considered. GA MACDONALD,1 SK ROBERTS,2 GJ DORE,3 EJ GANE,4 AJ THOMPSON,5 MD WELTMAN,6 F WEILERT,7 A HILL,8 J LÄUFFER,9 SI STRASSER10 1Department Epigenetics Compound Library research buy of Gastroenterology and Hepatology and the School of Medicine, The University of Queensland, Princess Alexandra Hospital, Queensland, Australia, 2The Alfred Hospital, Melbourne, Victoria, Australia, 3Kirby Institute, The University of New South Wales, St Vincent’s Hospital, Sydney, Australia, 4NZ Liver Unit, Auckland City Hospital, Auckland, New Zealand, 5Department of

Gastroenterology, St Vincent’s Hospital Melbourne and the University of Melbourne, Victoria, Australia, 6Nepean Hospital, Kingswood, NSW, Australia, 7Waikato Hospital, Hamilton, New Zealand, 8MetaVirology Ltd, London, LY2835219 supplier UK, 9Janssen-Cilag AG, Zug, Switzerland, 10Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia Background Diflunisal and aims: HEP3002 is an ongoing, open-label, early access program of telaprevir

in 16 countries, for patients with genotype 1 hepatitis C with severe fibrosis or compensated cirrhosis. This interim analysis is of 16 week data from the 81 patients from Australia and New Zealand. Methods: Patients were treated with telaprevir in combination with peginterferon alfa and ribavirin (PR) for 12 weeks, followed by PR for 36 weeks. Severe fibrosis / cirrhosis was defined by liver biopsy (Metavir F3–4 or Ishak 3–6) or non-invasive tests. Platelet count >90,000/mm3 was required at entry. HCV RNA was evaluated at baseline and Weeks 4 and 12 of treatment. Virological response was defined as serum HCV RNA not detected, for the Intent to Treat (ITT) population. Results: Mean age was 53 years; 80% were male and 88% Caucasian, 72% had HCV RNA levels ≥800,000 IU/mL, 25%/70% had severe fibrosis/cirrhosis, 5% were F1 or F2, 75% had genotype 1a, 44% were treatment naïve, 27% prior relapsers, 5% prior partial responders, 22% prior null responders and 1% had prior viral breakthrough. At baseline, the median platelet count was 163 × 109/L (IQR: 128–200) and median albumin was 42 g/L (IQR: 38–44); 4 patients (5%) had platelets <100 × 109/L and 1 patient (1%) had albumin <35 g/L.