1.4 Where pegylated interferon or adefovir is being used to treat HBV in a woman who does not yet require HIV treatment who discovers she is pregnant, treatment should be switched

to a tenofovir-based HAART regimen. Grading: 1C 6.1.5 As there is no evidence of any adverse effect on maternal or neonatal health if women become pregnant while taking ART active against HBV these should be continued. Grading: 1C 6.1.6 In all HAV non-immune HBV coinfected women HAV vaccine is recommended, after the LDK378 first trimester, as per the normal schedule (0 and 6–12 months) unless the CD4 cell count is <300 cells/μL when an additional dose may be indicated. Grading: 1D 6.1.7 Tenofovir and emtricitabine should form the backbone of an ART regimen in naïve patients with wild-type HIV/HBV infection and no contraindication to either drug. Grading: 1B 6.1.8 If tenofovir is not currently part of HAART, it should be added. Grading: 1B 6.1.9 Lamivudine/emtricitabine selleck chemicals llc may be omitted from the ARV regimen and tenofovir given as the sole anti-HBV agent if there is clinical or genotypic evidence of lamivudine/emtricitabine resistant HBV. Grading: 1C 6.1.10 Lamivudine or emtricitabine should not be used as the only active drug against HBV in HAART because of the likelihood of emergent HBV resistance to these agents. Grading: 1B 6.1.11 Emtricitabine has potential antiviral benefits over lamivudine, is co-formulated

with tenofovir and appears to be equally safe during pregnancy and hence is the preferred option

to be given with tenofovir in coinfection. Grading: 2D 6.1.12 Where the CD4 cell count is <500 cells/μL HAART should be continued postpartum if HBV coinfection exists because of the increased risk of HBV progressive disease. Grading: 1B 6.1.13 Where the CD4 cell count is >500 cells/μL and there is no other indication to treat HBV, consideration should be given to continuing anti-HBV treatment postpartum with HAART incorporating tenofovir and emtricitabine. Grading: 2C 6.1.14 If a decision is taken to discontinue therapy postpartum, careful monitoring of liver function Galeterone is imperative. Grading: 2D 6.1.15 Where the CD4 cell count is >500 cells/μL and there is HBV viraemia and evidence of liver inflammation or fibrosis, HAART containing tenofovir and emtricitabine should be continued. Grading: 2C 6.1.16 Hepatitis flares that occur after HAART cessation should be treated by resumption of active anti-HBV treatment before significant liver dysfunction occurs. Grading: 2D 6.1.17 In the absence of obstetric complications, normal vaginal delivery can be recommended, if the mother has fully suppressed HIV VL on HAART. Grading: 2C 6.1.18 Neonatal immunization with or without hepatitis B immunoglobulin (HBIG) should commence within 24 h of delivery. Grading: 1A 6.2.1 On diagnosis of new HCV infection, confirmation of HCV viraemia with quantitative VL and genotype, assessment of hepatic inflammation and function and concomitant liver disease should be performed. Grading: 1C 6.2.