4 2677.5 ± 486.5 2048.5 ± 279.8 Available nitrogen (g/m2) 5.9 ± 2 7.1 ± 1.3 4.6 ± 1.9 6 ± 1.5 7.1 ± 1.1 Salinity (mg/l) 0.4 ± 0.2 0.4 ± 0.2 0.3 ± 0.1 0.2 ± 0.1 0.1 ± 0.1 Dominant landscape agea 4.6 ± 3.7 4.1 ± 2.5 2.7 ± 2.4 5.8 ± 2.9 5.6 ± 2.9 Relative humidity in spring (%) 81.3 ± 1.5 80.1 ± 1.4 78.3 ± 1.8 77.1 ± 1.6 76.3 ± 0.5 Duration of sunshine (h) 1609.4 ± 47.9 1535 ± 44.5 1482.5 ± 33.4 1471.2 ± 43.7 1473.1 ± 17.2 Amount of radiation (Joule/m2) 37.2 ± 1.0 35.4 ± 0.7 34.7 ± 0.3 35.1 ± 0.6 35.7 ± 0.2 Temperature (°C) 9.9 ± 0.4 9.5 ± 0.3 9.3 ± 0.2 9.7 ± 0.3 9.9 ± 0.1 Precipitation surplus (mm) 216.9 ± 37.2 252.7 ± 25.7 282.8 ± 45.3 227.8 ± 39.5 221.5 ± 38.3 Poor sandy soils (km2) 3.1 ± 4.0

3.3 ± 5.6 12.4 ± 7.1 7.9 ± 5.7 1.0 ± 2.3 Rich sandy soils (km2) 1.5 ± 2.8 2.4 ± 4.4 7.5 ± 6.1 9.3 ± 6.0 0.7 ± 2.2 Calcareous sandy soils (km2) 5.1 ± 5.4 0.4 ± 1.5 0.1 ± 0.5 0.2 ± 0.6 0.1 ± 0.4 Non-calcareous clay (km2) 2.9 ± 4.2 5.4 ± 5.8 1.2 ± 3.5 2.0 ± 3.5 4.8 ± 5.4 Calcareous clay Semaxanib (km2) 2.6 ± 4.9

2.3 ± 5.5 0.3 ± 1.7 1.3 ± 3.6 0.4 ± 0.7 Non-calcareous loam (km2) 0.0 ± 0 0.0 ± 0 0.1 ± 0.4 0.32 ± 1.3 11.5 ± 8.3 Peat soils (km2) 0.4 ± 0.9 6.9 ± 7.2 1.6 ± 2.6 0.8 ± 2.1 0.2 ± 0.8 Heterogeneity of landscape types (H) 1.3 ± 0.3 1.2 ± 0.3 1.4 ± 0.2 1.4 ± 0.3 1.3 ± 0.2 Agricultural areas (km2) 8.4 ± 6.7 15.8 ± 5.1 12.6 ± 6.8 14.6 ± 5.0 13.4 ± 5.1 Mizoribine clinical trial Urbanized areas (km2) 6.4 ± 5.7 4.2 ± 3.8 3.6 ± 3.2 5.0 ± 4.3 7.5 ± 4.7 Deciduous forest (km2) 1.5 ± 1.7 0.5 ± 0.6 1.9 ± 1.3 1.5 ± 0.9 1.5 ± 0.8 Coniferous forest (km2) 5.1 ± 1.0 0.1 ± 0.4 4.2 ± 4.6 2.0 ± 2.4 0.2 ± 0.9 Salt marshes (km2) 0.1 ± 0.4 0.0 ± 0 0.0 ± 0 0.0 ± 0 0.0 ± 0 Dune vegetation (km2) 2.9 ± 3.8 0.0 ± 0 0.0 ± 0 Edoxaban 0.0 ± 0 0.0 ± 0 Heath (km2) 0.0 ± 0 0.0 ± 0 1.0 ± 1.9 0.2 ± 0.6 0.0 ± 0 Peat bog (km2) 0.0 ± 0 0.0 ± 0 0.1 ± 1.1 0.1 ± 0.7 0.0 ± 0 Sedge vegetation (km2) 0.00 ± 0 0.5 ± 1.3 0.0 ± 0 0.0 ± 0 0.0 ± 0 Marsh (km2) 0.1 ± 0.2 0.6 ± 1.3 0.0 ± 0 0.0 ± 0 0.0 ± 0 Fen areas (km2) 0.0 ± 0 0.1 ± 0.6

0.0 ± 0 0.0 ± 0 0.0 ± 0 Other natural areas (km2) 0.2 ± 1.3 0.5 ± 0.7 0.8 ± 0.8 0.4 ± 0.5 0.1 ± 0.1 Freshwater (km2) 0.9 ± 1.6 2.6 ± 3.0 0.3 ± 0.6 0.6 ± 0.9 0.6 ± 1.1 Nature (%) 5.3 ± 4.8 2.3 ± 2.5 8.2 ± 6.7 4.2 ± 3.2 1.9 ± 1.2 n = number of 5 × 5 km squares included in each region aEleven landscape age classes were defined: 1 (1000–1299); 2 (1300–1499) 3 (1500–1700); 4 (1701–1800); 5 (1801–1850); 6 (1851–1900); 7 (1901–1920); 8 (1921–1940); 9 (1941–1960); 10 (1961–1990); 11 (1991–2004).