6 mm versus 21 mm). Representative cases are illustrated in Fig. 1. There were nine cases (24%; cases 2, 13, 17, 22, 27, 29, 30, 33, 45) showing disagreement between routine histological analysis and combined Compound Library datasheet histological analysis. Immunohistochemistry was in agreement with the final diagnosis of surgical specimens in six cases (67%) by correctly reclassifying five HCAs that were initially considered unclassified on routine histological analysis into three telangiectatic/inflammatory and two steatotic LFABP-negative. Data are provided in Table 1. Subtyping of hemorrhagic HCAs was possible in all cases. The diagnostic results

of the two radiologists, routine and combined histological analysis by HCA subtype are set out in Table 2. Representative cases are illustrated in Figs. 2-4. The distribution of patients having MR features suggestive of either steatotic LFABP-negative HCAs or telangiectatic/inflammatory HCAs are shown in Figs. 5 and 6. In addition, there were no statistical differences in correct subtyping between HCA

<5 cm and those >5 cm (imaging: 80% versus 87.5% P = 0.45, routine biopsy: 66.7% versus 81.3%, P = 0.27, and combined biopsy analysis 75% versus 84.6%, (P = 0.48). Agreement between the evaluation of MRI findings by the senior radiologist and routine histological Autophagy inhibitor analysis was 74.5% (CI: 59%-87%) corresponding to a kappa value of 0.54 (CI: 0.34-0.74). There was disagreement in 12 cases (cases 6, 9, 17, 22, 30, 31, 32, 33, 36, 37, 41, 47). Correct classification was obtained at MRI and biopsy in seven and three cases, respectively. In 2/12 cases (17%) the lesions were misclassified by both. Agreement between assessment of MRI findings by the senior radiologist and the combined histological analysis was 63.2% (CI: 45%-79%) (kappa = 0.36,

CI: 0.13-0.60). There was disagreement in 14 cases (cases 2, 6, 9, 13, 22, 27, 29, 32, 33, 36, 37, 41, 45, 47). Correct classification was obtained at MRI and immunohistochemistry in seven and seven cases, respectively. Diagnostic values and likelihood ratios when MRI and routine histological analysis agreed were further assessed according to HCA subtypes. MRI and routine histological analysis were in agreement and correct in classifying 25 of the 34 cases of telangiectatic/inflammatory HCA (sensitivity 73.5%; CI: 55%-88%). this website None of the HCAs were incorrectly classified as telangiectatic/inflammatory (specificity 100%; CI: 75%-100%). When there was agreement for a diagnosis of telangiectatic/inflammatory subtype, the LR was 20.4 (CI: 1.3-313). MRI and routine histological analysis were in agreement and correct in classifying 7 of the 11 cases of steatotic LFABP-negative HCAs (sensitivity 63.6%; CI: 30%-90%). Only one HCA was incorrectly labeled steatotic (specificity 97,2%; CI: 85%-100%). When they agreed on the diagnosis of steatotic, the LR was 22.9 (CI: 3.1-167).