7 1.7 16.5 22.3 318 1.4 16.5 24.7 selleck inhibitor Serogroup C1 Choleraesuis c 1,5 0 0 0.03 4.2 0 0 0.05 4.3 0.03 0 0.02 2.0 Grampian r l,w 0 0 0 0 0 0 0 0 0 0 0 0 Hissar c 1,2 0 0 0 0 0 0 0 0 0 0 0 0 Redba z10 z35 0 0 0 0 0 0 0 0 0 0 0 0 Serogroup C2-C3 Blockley k 1,5 0 0 0.18 0 0 0 0.23 0 0.05 0 0.14 0 Albany Z4,z24 – 0 0 0.05 4.7 0.6 0 0.09 3.4 0.03 0 0.10 4.9 Serogroup D1 Enteritidis [f],g.m. [p] [1, 7] 3.8 5.2 13.1 22.7 9.8 1.8 14.10 22.9 4.7 4.5 18.6 24.4 Serogroup E Anatum e,h 1,6: [z64] 0.5 0.6 0.47 1.0 0 0 0.7 1.1 0.64 0.6 0.54 0.7 Serogroup G
Havana f,g, [s] – 0.2 1.2 0.08 0 0.6 0.7 0.089 0.1 0.27 0.8 0.07 0 Total Salmonellae Foretinib 2038 924 37442 529 164 717 35661 2557 3743 665 36214 2228 adata from Salmonella Annual Summary for clinical Salmonella isolates from nonhuman and human sources reported to the Disease Control and Prevention (CDC) and the USDA National Veterinary Services Laboratory (NSVL), USA. bdata from Annual Report and Accounts 2008/2009 of Veterinary Laboratory Agency, Department CYC202 mouse of Environment, Food and Rural Affairs, United Kingdom. Discussion As one of main pathogen to cause foodborne diseases, Salmonella has been frequently reported
among different animal sources, especially more divergent Salmonella serovars found in chickens [34]. With the limited serovars in 164 chicken isolates, serogroups C2, D, E and G were restricted in one county and serogroup B and C1 were found in all three counties (Table 2), suggesting possibly that serogroup B and C1 isolates may be
more adapted to chicken. In human isolates, we found that the serovar number in each serogroup were not associated positively with the serogroup prevalence, such as highest serovar number in low prevalent serogroup C1 vs lower serovar number in high prevalent serogroup B and serogroup D (Table 4). These results imply that serogroup C1 may occasionally infect human isolates. Further, serovars are determined by flagellins: H1 and H2 antigens encoded by fliC and fljB. As one of the most important immunogens, flagellin interacts with the toll-like receptor 5 (TLR5) to activate NFκB pathway and proinflammatory Branched chain aminotransferase genes to regulate innate and adaptive immune system [35–38]. However, aflagellar serovars S. Pullorum and S. Gallinarum cause more severe infection than flagellar serovars in chicken because of aflagellar S. Typhimurium could avoid the TLR5 regulation of IL-1β expression and polymorphonuclear cell infiltration in gut [39]. Such evasion of TLR5 is critical for survival of flagellar bacteria at muscos [40]. [In the present study, we found that i of H1 antigen and lack of H2 antigen were the common antigens for all serogroups in human isolates (Table 4).