96[0.94-0.98], P<0.001) and out-of-hospital arrest (HR[95%CI] = 2.04[1.14-3.62], P=0.02) were independent predictors of in-hospital mortality and mean PP over the

first 6h after ECLS implantation (HR[95% CI] = 0.95[0.93-0.98], P<0.001) was the sole independent predictor of weaning failure.

Conclusion: Higher mean PP over the initial 6h after ECLS implementation independently predicted successful weaning and survival. Our findings may help better predict and analyze prognosis in patients receiving ECLS. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Objective: To study the correlation between the degree of endolymphatic hydrops as detected in vivo by magnetic resonance (MR) imaging and the auditory and vestibular function in patients with definite Meniere’s disease.

Study Design: Prospective IACS-10759 in vivo observational study.

Setting: Tertiary referral center for balance disorders.

Subjects and Methods: In this

prospective study, 41 patients who fulfilled the criteria for definite unilateral Meniere’s disease according to the American Association of Otolaryngology-Head and Neck Surgery GSK2118436 and who showed a summating potential-to-action potential ratio of greater than 0.4 on electrocochleography were included. Intratympanic contrast-enhanced 3 Tesla MR imaging of the inner ear was LGK974 performed

using a 3D Inversion Recovery Turbo Spin Echo sequence. The degree of endolymphatic hydrops was graded on a Likert scale (0-3) in the cochlea and by vestibular endolymph space ratio in the vestibulum. The degree of hydrops was then analyzed with respect to its correlation with audiometric hearing levels, interaural amplitude ratios of vestibular evoked myogenic potentials, degree of horizontal semicircular canal paresis on caloric irrigation, and disease duration.

Results: The degree of hearing loss and the disease duration correlated significantly with cochlear hydrops (r = 0.85; r = 0.34). Sacculus dysfunction was significantly correlated with vestibular hydrops (r = -0.47). There was no significant correlation between horizontal semicircular canal paresis and vestibular hydrops.

Conclusion: In patients with clinically and electrocochleographically confirmed definite Meniere’s disease, the degree of MR morphological hydrops severity correlates significantly with impairment of hearing function and sacculus function.”
“Purpose

We retrospectively determined the efficacy and safety of the combination of oxaliplatin, 5-fluorouracil (5-FU), and folinic acid (FA) as first-line chemotherapy for patients with metastatic or recurrent gastric cancer.