Circ Res 2004, 95: 568–78.PubMedCrossRef 22. Meyer MR, Haas E, Barton M: Gender differences of cardiovascular disease: new perspectives for estrogen receptor signaling. Hypertension 2006, 47: 1019–26.PubMedCrossRef 23. Atanaskova N, Keshamouni VG, Krueger JS, Schwartz JA, Miller F, Reddy KB: MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer LDK378 tamoxifen resistance. Oncogene 2002, 21: 4000–8.PubMedCrossRef 24. Martin LA, Farmer I, Johnston SR, Ali S, Dowsett M: Elevated ERK1/ERK2/estrogen receptor cross-talk enhances estrogen-mediated signaling

during long-term estrogen deprivation. Endocr Relat Cancer 2005, 12 (Suppl 1) : S75–84.PubMedCrossRef 25. Santen RJ, Song RX, McPherson R, et al.: The role of mitogen-activated protein (MAP)

kinase in breast cancer. J Steroid Biochem Mol Biol 2002, 80: 239–56.PubMedCrossRef 26. learn more Migliaccio A, Pagano M, Auricchio F: Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells. Oncogene 1993, 8: 2183–91.PubMed 27. Auricchio A, di Domenico M, Castoria G, Bilancio A, Migliaccio A: Epidermal growth factor induces protein tyrosine phosphorylation and association of p190 with ras-GTP-ase activating protein in Caco-2 cells. FEBS Lett 1994, 353: 16–20.PubMedCrossRef 28. Auricchio F, Migliaccio A, Castoria G, Di Domenico M, Bilancio A, Rotondi A: Protein tyrosine phosphorylation and estradiol action. Ann

N Y Acad Sci 1996, 784: 149–72.PubMedCrossRef Selleckchem LY2835219 29. Migliaccio A, Piccolo D, Castoria G, et al.: Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO J 1998, 17: 2008–18.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions WWZ carried out the design of the study, performed IHC, real-time PCR, drafted the manuscript. LHO performed Sulfite dehydrogenase the western blot. WYH participated in SPSS Statistical Analysis. LYH participated in IHC and IOD scoring. WWB participated in real-time PCR and cell culture. ZL performed SPSS Statistical Analysis. HY and YJW participated in IHC. SLL participated in collection of breast cancer specimens. XJJ participated in the design of the study, drafted the figure. YXJ performed the design of the study, and helped drafting the manuscript. GJX performed the collection of breast cancer specimens. All authors read and approved the final manuscript.”
“Background Gastric cancer is a significant health problem in most developing countries, including China, and is the second leading cause of cancer death worldwide [1]. The exact cause of gastric cancer has been elusive and the risk factors identified to date are variable and include helicobacter pylori infection, tobacco smoking, alcohol consumption and unhealthy diet.