Conclusion Consumption of low calorie ED and thermogenic beverages have been reported to increase resting energy expenditure and fat metabolism on an acute basis. Preliminary studies suggest that A-1155463 in vivo ingesting some types of ED and thermogenic beverages prior to exercise during training could promote positive adaptations in body composition. However, more research is needed to determine whether daily

use of ED would affect long-term energy balance and body composition. Safety considerations ED have had a negative connotation in the media and more recently medical community, mostly related to potential concerns about excessive caffeine intake [201, 202] and/or potential deleterious effects of mixing ED with alcohol [203]. While safety concerns and use of alcohol go beyond Selleck Vorinostat the scope of this paper, the reader is referred to a recent viewpoint published in the Journal of the American Medical Association related to safety concerns of mixing ED with alcohol [203]. In terms of use of ED in the traditional sense, most concerns have been based on case studies or adverse event reports that have serve only to document a potential association, but does not establish causality. In reality,

this website there are currently only a few studies (acute or long term) that have investigated the side effects of ED [204–209]. There appear to be two primary active nutrients in most ED and ES (i.e., carbohydrate and caffeine) that may possess safety concerns in some populations. Many ED contain 25 – 50 g of simple sugars, therefore, ingestion of ED prior to exercise are likely to rapidly increase insulin in order to maintain normal blood glucose levels. For this reason, diabetics and pre-diabetics should avoid high glycemic load ED or consider consuming low carbohydrate versions of ED [201, 202]. Very often, ED also contain various stimulants with the most common being caffeine. Some concern has been raised about excessive caffeine intake that could be obtained from consuming too many ED and/or from a lack of knowledge that that some ingredients contained in ED may contain caffeine

[201, 202]. Currently in the United States, the FDA has regulated the limit of caffeine in soft drinks to 0.02 percent Tangeritin (10mg/oz.) of the product, but this is not currently enforced for ED or ES. As of December 2012, the US-FDA along with the US Congress has begun to study products marketed as ED or ES, however no formal new guidelines have been published. The Nutrition Facts Panel on food labels are not required to always list caffeine since it is not a nutrient. However, if caffeine is added to a food, it must then be listed [210]; therefore many individuals may consume more caffeine than they realize [201, 202]. In Canada, caffeine levels are limited to 180 mg per drink [211]. The caffeine content of common ED and ES has been reported to range from about 100 to 286 mg [202].