Conclusions-Rare nonsynonymous variants identified in DCM subjects also present at very low frequencies in public databases are likely relevant for DCM. Allele frequencies >0.04% are of GDC-0068 in vivo less certain pathogenicity, especially if identified in sporadic cases, although this cutoff should be viewed as preliminary. (Circ Cardiovasc Genet. 2012;5:167-174.)”
“Utilizing metal-vanadium oxide (VO2)-semiconductor capacitor device structures, we have investigated the temperature- and frequency-dependent dielectric and ac conductance responses of vanadium oxide thin films that undergo metal-insulator transition (MIT). In both metallic and insulating regimes, VO2-based devices
showed large tunabilities as high as similar to 95% and similar to 42%-54%, respectively. The frequency AZD9291 concentration dependence of capacitance and ac conductance displays power-law behavior with respect to temperature and applied voltage over a broad range. Low-frequency dispersion in dielectric properties was also observed and their onset frequency varies across the MIT from similar to 0.5 MHz in insulating state to similar to 50 kHz in metallic state. The results are of potential relevance to utilizing functional oxides in electronic devices.”
“Mechanical properties such as tensile and impact strength behavior of teak wood flour (TWF)-filled high-density polyethylene (HDPE) composites were evaluated at 0-0.32 volume fraction (Phi(f))
Bafilomycin A1 of TWF. Tensile modulus and strength initially increased up to Phi(f) = 0.09, whereas a decrease is observed with further increase in the Phi(f). Elongation-at-break and Izod impact strength decreased significantly with increase in the Phi(f). The crystallinity of HDPE also decreased with increase in the TWF concentration. The initial increase in the tensile modulus and strength was attributed to the mechanical restraint, whereas decrease in the tensile properties at Phi(f) > 0.09 was due to the predominant
effect of decrease in the crystallinity of HDPE. The mechanical restraint decreased the elongation and Izod impact strength. In the presence of coupling agent, maleic anhydride-grafted HDPE (HDPE-g-MAH), the tensile modulus and strength enhanced significantly because of enhanced interphase adhesion. However, the elongation and Izod impact strength decreased because of enhanced mechanical restraint on account of increased phase interactions. Scanning electron microscopy showed a degree of better dispersion of TWF particles because of enhanced phase adhesion in the presence of HDPE-g-MAH. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 112: 1826-1834, 2009″
“Background-A number of single gene defects have been identified in patients with isolated or nonsyndromic congenital heart defects (CHDs). However, due to significant genetic heterogeneity, candidate gene approaches have had limited success in finding high-risk alleles in most cases.