Figure 1 Computer tomography scan (CT) with intra-venous contrast of the abdomen. (A) coronal CT projection depicting gastric outlet obstruction, haepato-billiary dilatation, cystic features due to a serous pancreatic cystadenoma, and a left clear renal cell carcinoma; … Figure 2 Permanent histological

sections. (A) pancreatic serous cystadenoma; (B) clear renal cell carcinoma. A staged operation was planned. First, as dictated by the patient symptoms, we prioritized the gastric and biliary drainage to be followed by partial Inhibitors,research,lifescience,medical left nephrectomy. Major pancreatic resection and dissection of the hepatic pedicle-common bile duct were limited by the concomitant portal hypertension. A gastric and biliary drainage consisting of gastrojejunostomy and cholecystojejunostomy was planned. A mini laparotomy (10 cm) supra-umbilical

incision was made and an antecolic anterior stapled gastro-jejunostomy was performed. A segment of proximal jejunum 20 cm from the ligament of Trietz was secured with interrupted 3-0 silk stiches to the anterior gastric wall and anastomosed Inhibitors,research,lifescience,medical side-to-side with 75 mm gastro-intestinal anastomosis (GIA-75) with the point of entry of the staple controlled and closed using 60 mm thoraco-abdominal (TA-60) blue load staplers. Along the same jejunal limb, 15 cm distal to the gastro-jejunostomy, a hand sewn cholecysto-jejunostomy was performed Inhibitors,research,lifescience,medical through an omentoplasty sleeve. The omental sleeve was performed to seal any potential biliary leak from the cholecystojejunostomy. After, the gallbladder was secured in position Inhibitors,research,lifescience,medical with non transfixing 5-0 polydioxanone (PDS), its inferior posterior aspect was opened for about 1.5 cm with electro-cautery allowing for bile aspiration and confection of the cholecysto-jejunostomy with a running 5-0 PDS. The anastomosis Inhibitors,research,lifescience,medical was internally stented using 8 Fr pediatric feeding tube. Finally, a sentinel 19 Fr. Blake drain was placed around the bilio-enteric anastomosis. The patient had a smooth postoperative recovery with no morbidities and the diet was advanced gradually

with immediate resolving of her preoperative nausea and vomiting. She was discharged home on the fifth postoperative day. The Blake drain was removed during a clinic visit with near null aminophylline output approximately one week from date of discharge. At one month postoperatively, the patient reported improved oral intake and 18 lbs weight gain. Furthermore, aspartate transaminase, alanine transaminase, total bilirubin, and alkaline phosphatase have all trended towards normalization (32, 29, 151 U/L, and 0.6 mg/dL, respectively) IAP inhibitor clinical trial corroborating a successful hepato-biliary decompression. Notwithstanding unchanged home doses of metformin and long-acting insulin, and despite resumption of oral intake, average HgbA1c levels diminished from 16.4% to 11% at three months after the surgery. The patient underwent subsequently an uneventful partial left nephrectomy and recovered well from her second surgery.