Fisher and Timothy B. Gardner Endoscopic therapy has become an essential component in the management of post-pancreatitis complications, such as infected and/or symptomatic pancreatic pseudocysts and walled-off necrosis. However, although there have been 2 recent randomized, controlled trials performed, a general lack of comparative effectiveness data regarding the timing, indications,

and outcomes of these procedures Navitoclax in vivo has been a barrier to the development of practice standards for therapeutic endoscopists managing these issues. This article reviews the available data and expert consensus regarding indications for endoscopic intervention, timing of procedures, endoscopic technique, periprocedural considerations, and complications. Jason R. Roberts and Joseph Romagnuolo Cobimetinib nmr Endoscopy plays an important role in both the diagnosis and the initial management of recurrent acute pancreatitis, as well as the investigation of refractory disease, but it has known limitations and risks. Sound selective use of these therapies, complemented with other lines of investigation such as genetic testing, can dramatically improve frequency of attacks and associated quality of life. Whether endoscopic therapy can reduce progression to chronic pancreatitis, or reduce the risk of malignancy, is debatable, and remains to be proven. Jean-Marc Dumonceau Endoscopic therapy is

recommended as the first-line therapy for painful chronic pancreatitis with an obstacle on the main pancreatic duct (MPD). The clinical response should be evaluated at 6 to 8 weeks. Calcified stones that obstruct the MPD are first treated by extracorporeal shockwave lithotripsy; dominant MPD strictures are optimally treated with a single, large, plastic stent that should be exchanged within 1 year even in asymptomatic patients. Pancreatic pseudocysts for which therapy is indicated and are within endoscopic reach should be treated by endoscopy. Pietro Familiari, Ivo Boškoski, Vincenzo Bove, and Guido Costamagna Chronic

pancreatitis (CP)-related common bile duct (CBD) strictures are more difficult to treat endoscopically compared with benign Avelestat (AZD9668) biliary strictures because of their nature, particularly in patients with calcific CP. Before any attempt at treatment, malignancy must be excluded. Single plastic stents can be used for immediate symptom relief and as “bridge to surgery and/or bridge to decision,” but are not suitable for definitive treatment of CP-related CBD strictures because of long-term poor results. Temporary simultaneous placement of multiple plastic stents has a high technical success rate and provides good long-term results. Jessica Widmer, Reem Z. Sharaiha, and Michel Kahaleh Over the last 2 decades there has been continuing development in endoscopic ultrasonography (EUS).