Gut permeability, pellet output, colonic mast cell number and plasma levels of ACTH and corticosterone also were analyzed. HE-400 was administered orally for 4 days prior to the period of restraint stress as preventive treatment or a single dose was given as an acute treatment. Effects were compared to rats treated either ZVADFMK with vehicle or commonly used comparator
medications. Results: HE-400 significantly reduced stress-induced colonic hypersensitivity to distension when administered during the 4-day period prior to restraint stress. A single acute dose of HE-400 significantly reduced stress-induced increases in colonic permeability as well as activation of mucosal mast cells. In addition, oral treatment with HE-400 during the 4-day preventive period significantly prevented the reduced colonic transit time as well as the increase in plasma ACTH that normally occurs following restraint stress. Conclusion: We conclude that HE-400 has the ability to modify Selleckchem TSA HDAC multiple pathological pathways associated with an acute restraint stress in rats such as colonic hypersensitivity, permeability, mucosal mast cell numbers and colonic transit time. These findings suggest that this multicomponent / multitarget medication could be used either alone or included
as an effective adjunctive therapy for patients with IBS. Key Word(s): 1. IBS; 2. stress, pain; 3. motility, mast cells; 4. medication; Presenting Author: HAILONG CAO Additional Authors: BANGMAO WANG Corresponding Author: BANGMAO WANG Affiliations: Tianjin General Hospital, Tianjin Medical University, China; Tianjin General Hospital, Tianjin Medical University, China Objective: Previous studies reported that gastric fundic
gland polyps (FGPs) and adenomatous polyps find more (APs) seemed to increase the risks of colorectal neoplasia. However, data were controversial, and information about hyperplastic polyps (HPs) was limited. We aimed to identify the relationships between different gastric polyps and colorectal neoplasia. Methods: Patients who underwent both esophagogastroduodenoscopy and colonoscopy within six months were analyzed. Data including age, sex, and histology of polyps were recorded. Each patient was compared with two randomly selected age and sex matched controls in the same period. Results: A total of 940 cases in 78 356 consecutive patients were diagnosed as gastric polyps, and 331 patients including 185 FGPs, 93 HPs, and 53 APs underwent colonoscopy. Colorectal neoplasias were detected in 43 FGPs (23.2%), 20 HPs (21.5%), and 21 APs patients (39.6%), respectively, and an increased incidence of colorectal neoplasia (mainly adenoma) in 331 gastric polyps compared to controls was found. Specifically, incidences were significantly increased in elderly or female FGPs, multiple HPs, and APs (regardless of age, sex and polyps number).