Here we report a case of an extensive retroperitoneal abscess formation with Citarinostat order rectal perforation and portal venous gas embolization after necrotizing acute appendicitis in a young male patient. Case report A 43-year old man was admitted to the Emergency Department with progressive abdominal pain, nausea, reduction in defecatory frequency and change in stool appearance as hard separate lumps that started almost three weeks before, and in addition, new onset of anal bleeding. There were no preexisting

co-morbidities. The patient had tachycardia (up to 140 bpm), arterial hypertension see more (170/70 mmHg) and fever (38°C). Clinical examination revealed an abdominal distension with a palpable mass in the lower abdomen, as well as signs of peritoneal irritation. The rectal examination was very painful, and an ulcerative lesion was perceived on the anterior rectal wall. Anal bleeding

could be confirmed. The laboratory findings revealed increased C-reactive protein (CRP) levels up to 100 mg/l, leucocytes 8.8 G/l, and serum lactate levels of 4.5 mmol/l. The abdominal CT scan with only IV contrast showed a perforation of the anterior rectal wall, 10 cm proximally from the anorectal border with multiple, partially confluent large abscesses located extra- and retroperitoneally (Figure 1). A significant air collection ascended from the lower LY2090314 concentration pelvis through the retroperitoneal space up to the left kidney (Figure 2). Finally, massive hepatic portal venous gas was detected (Figure 3). Due to a coprolith

and local abscess formation, appendiceal perforation was also highly suspected (Figure 1). Figure 1 CT Scan showing a necrotic appendix with a stercolith (long arrow) and anterior wall perforation (short arrow). Figure Dolichyl-phosphate-mannose-protein mannosyltransferase 2 Retroperitoneal phlegmon with some air bubbles. Figure 3 Hepatic portal venous gas in several intrahepatic portal branches. The patient underwent emergency laparotomy. Intraoperatively, a necrotizing appendicitis was found with multiple abscess formation in the retroperitoneal space. The abscess extended from the perirectal area in the pelvis up to the left kidney. The sigmoid colon, the upper and mid rectum were surrounded by the abscess. Perforation of the anterior rectal could be confirmed. Sigmoid and the upper two third of the rectum were resected, and a Hartmann’s situation created. The appendix was excised and all abscess were drained by widely opening the retroperitoneal space. Due to the severe sepsis, the patient stayed for three days in the ICU, and another 18 days on the normal ward. Initial blood cultures were positive to Bacterioides fragilis and turned sterile after a week. Cultures of the abscesses were positive to Bacterioides fragilis, Escherichia coli and Streptococcus anginosus. IV antibiotic treatment (Piperacillin-Tazobactam 4.