Infect Immun 1993, 61:1764–1771.PubMed 77. Nuijten PJ, Berg AJ, Formentini I, Zeijst BA, Jacobs AA: DNA rearrangements in the flagellin locus of an flaA mutant of Campylobacter jejuni during colonization of chicken ceca. Infect Immun 2000, 68:7137–7140.CrossRefPubMed 78. Yao R, Burr DH, Doig P,

Trust TJ, Niu H, Guerry P: Isolation of motile and non-motile insertional mutants of Campylobacter jejuni : the role of motility in adherence and invasion of eukaryotic cells. Mol Microbiol 1994, 14:883–893.CrossRefPubMed 79. see more Lipinska B, Fayet O, Baird L, Georgopoulos C: Identification, characterization, and mapping of the Escherichia Lazertinib coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures. J Bacteriol 1989, 171:1574–1584.PubMed 80. Skorko-Glonek J, Lipinska B, Krzewski K, Zolese G, Bertoli E, Tanfani F: HtrA heat shock protease interacts with phospholipid membranes and undergoes conformational changes. J Biol Chem 1997, 272:8974–8982.PubMed 81. Skorko-Glonek J, Wawrzynow A, Krzewski K, Kurpierz K, Lipinska B: Site-directed mutagenesis of the HtrA (DegP) serine protease, whose proteolytic activity is indispensable for selleck chemicals llc Escherichia coli survival at

elevated temperatures. Gene 1995, 163:47–52.CrossRefPubMed 82. Spiess C, Beil A, Ehrmann M: A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein. Cell 1999, 97:339–347.CrossRefPubMed 83. Brøndsted L, Andersen MT, Parker M, Jorgensen K, Ingmer H: The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells. Appl Environ Microbiol 2005, 71:3205–3212.CrossRefPubMed 84. Purdy D, Cawthraw S, Dickinson JH, Newell DG, Park SF: Generation of a superoxide dismutase (SOD)-deficient mutant of Campylobacter coli : evidence for the significance of SOD in Campylobacter survival and colonization. Appl Environ Microbiol 1999,

65:2540–2546.PubMed Authors’ contributions JEH carried out the proteomics experiments Avelestat (AZD9668) comparing 81–176 grown at 37°C and 42°C. KMR carried out all other experiments and participated in the study design and drafting of the manuscript. SAT conceived the study and participated in the study design and drafting of the manuscript. All authors read and approved the final manuscript.”
“Background Mycobacterium avium includes the subspecies avium, silvaticum, paratuberculosis and hominissuis [1–3]. The former, M. avium subsp. avium causes tuberculosis in captive and free living birds [4], while M. avium subsp. hominissuis is an opportunistic environmental pathogen for humans and swine, and occasionally also for other mammals [1].