Information on shapes, textures, intensities, and localizations is then used to create unique representations, or ‘phenotypic signatures,’ of each cell. These signatures quantify physiologic or diseased states, for example, dendritic arborization, drug response, or cell coping strategies. Live-cell imaging in HCS adds the ability to correlate cellular events at different points in time, thereby allowing sensitivities and observations not possible with fixed endpoint QNZ mouse analysis. HCS with live-cell imaging therefore provides an unprecedented capability to detect spatiotemporal changes in cells and is particularly suited

for time-dependent, stochastic processes such as neurodegenerative disorders.”
“This review presents recommendations for fluid needs and hydration assessment for recreational activity. Fluid needs are based on sweat losses, dependent on intensity find more and duration of the activity, and will vary among individuals. Prolonged aerobic activity is adversely influenced by dehydration, and heat exposure will magnify this effect. Fluid needs predicted for running 542 km at recreational paces show that fluid losses are <2% body

mass; thus, aggressive fluid replacement may not be necessary. Competitive paces result in greater fluid losses and greater fluid needs. Fluid needs for recreational activity may be low; however, carbohydrate consumption (sport drinks, gels, bars) can benefit high-intensity (<= 1 h) and less-intense, long-duration activity (>= 1 h). Spot measures of urine color or urine-specific gravity to

assess hydration status have limitations. First morning urine concentration and body mass with gross thirst perception selleck chemicals can be simple ways to assess hydration status. (C) 2012 International Life Sciences Institute”
“Plants in their natural environment frequently face various abiotic stresses, such as drought, high salinity, and chilling. Plant mitochondria contain an alternative oxidase (AOX), which is encoded by a small family of nuclear genes. AOX genes have been shown to be highly responsive to abiotic stresses. Using transgenic plants with varying levels of AOX expression, it has been confirmed that AOX genes are important for abiotic stress tolerance. Although the roles of AOX under abiotic stresses have been extensively studied and there are several excellent reviews on this topic, the differential expression patterns of the AOX gene family members and the signal regulation of AOX gene(s) under abiotic stresses have not been extensively summarized. Here, we review and discuss the current progress of these two important issues.”
“The most valuable lean cuts from Iberian pigs are the hams, forelegs, and loins, which yield high quality cured meat products.