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“Purpose: The remains unknown, To determine the analgesic and anti-inflammatory activities of Scrophularia megalantha in male rats in order to understand the scientific basis for its trado-medicinal uses, especially in inflammation.
Methods: The extract of Scrophularia megalantha was obtained with ethanol. In order to determine qualitatively the click here chemical components of the extract, thin layer chromatography (TLC) was used. The analgesic activity of the extract at various doses (25, 50, 100
and 200 mg/kg, i.p) was assessed using formalin test while pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA), respectively. Diclofenac (5 mg/kg) was used as positive control.
Results: Phenolic compounds, flavonoids and phenyl propanoid were present in the extract. At doses of 100 and 200 mg/kg, the extract showed significant analgesic effects (p < 0.05, p < 0.01) in the first phases of formalin test, compared with the control. At 25, 100 and 200 mg/kg doses,
the extract GSK3326595 cost reduced significantly (p < 0.05, p < 0.001, p < 0.001) pain score in the chronic phases of the formalin test. In addition, at 50 – 200 mu g/mL of the extractm both TNF-alpha and IL-6 proinflammatory cytokines were inhibited significantly (p < 0.001) on LPS-stimulated macrophages.
Conclusion: The extract of S. megalantha exerts analgesic and anti-inflammatory activities by inhibition of pro-inflammatory cytokines production. This lends support for the use of the plant as an analgesic in traditional medicine.”
“Objective: Rehabilitation of hearing
is complicated in patients with profound bilateral hearing loss in the presence of sporadic vestibular schwannoma (VS) or neurofibromatosis 2 (NF2), especially if the tumor does not need to be removed. We present the outcome of patients who have had a cochlear implant in the tumor affected ear without removal of the primary tumor.
Design: This is a retrospective multicentre study investigating outcomes of cochlear implantation in profoundly deaf patients with vestibular schwannoma in the implanted ear.
Materials and Methods: Out of 11 implanted patients, 5 required no treatment for their tumor, whereas 6 had previously undergone Crenigacestat radiotherapy. Nine patients experienced NF2, and 2 had unilateral VS in the only hearing ear. Postoperative hearing was assessed with open and closed set speech discrimination, including City University of New York (CUNY) in noise and Bamford, Kowal and Bench (BKB) sentence scores.
Results: Patients with untreated lesions experienced marked improvement in their BKB and CUNY scores in the implanted ear and were daily cochlear implant users. The improvement was less consistent in the patients who had radiotherapy where only 1 patient attained open set speech discrimination.