The coordinating center of the project is located at the national

The coordinating center of the project is located at the national Scientific Institute of Public Health selleck bio (WIV-ISP) and has two missions: the administrative coordination of the project (i.e. preparatory work for the MTAB, general follow-up of the conventions, management of the budget) and a scientific support for public health related aspects (i.e. assessment of the epidemiologic quality of the data, implementation of data transfer tools, public health expertise). Results Selection criteria pathogens As in our neighboring countries [8-10], infectious diseases were prioritized. In selecting which pathogens necessitated a NRC, 3 domains were defined based on their type of importance in public health. A first domain consisted of the pathogens with an impact on nosocomial transmission and antimicrobial resistance (e.

g. extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing EnterobacteriaceaeClostridium difficileStaphylococcus aureus). Pathogens from the second domain had an impact on surveillance, warnings and actions in the field of public health (e.g. Bordetella pertussis, rotavirus, Haemophilus influenzae, poliovirus). This domain includes the pathogens linked to vaccine-preventable diseases, diseases/pathogens requiring direct public health action by the health inspection (e.g. chemoprohylaxis) and pathogens subject to international commitments (e.g. eradication objectives). The last domain includes pathogens for which it is important that the diagnosis or confirmation takes place in one center where all necessary expertise is concentrated (e.g.

rabies virus, congenital infections, tick born encephalitis virus, West Nile virus, Clostridium botulinum). Included in this domain are the rare pathogens, the ones that are difficult to diagnose and those requiring a high biosafety level (BSL) such as emerging pathogens, or pathogens/diseases requiring a diagnostic confirmation in a specialized center. Some pathogens belonged to more than one domain. Forty (40) pathogens (Table (Table1)1) or groups of pathogens were prioritized and selected by the MTAB based Anacetrapib on an importance factor varying from moderate to high according to following criteria: burden of disease, severity, mortality, epidemiological dynamics including outbreak potential and emerging potential, information need for international duties and public health attention, health gain opportunity including preventability and treatability. Table 1 List of selected pathogens Within these 40 pathogens, five groups of pathogens (sexually transmitted infections (STI), respiratory pathogens, congenital infections, hepatitis and Salmonella/Shigella spp.) were defined, grouping different pathogens causing similar symptoms or having similar infection routes. Five other groups (e.g.

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