This varied histology is similar to that

of the previously described panfolliculoma, differing in that it emanates largely from the epidermis rather than being predominantly dermally located. We propose the term “”epidermal panfolliculoma”" for these lesions.”
“The effect of pitavastatin and SLCO1B1 genetic background on the pharmacokinetic and pharmacodynamic properties of repaglinide was investigated. In this randomized, placebo-controlled, crossover study, twelve healthy Chinese males were administered with pitavastatin 4 mg/d or the selleck chemical placebo for 5 d followed by repaglinide 4 mg given orally on d 5. Plasma repaglinide and glucose levels were measured by liquid chromatography-tandem mass spectrometry (LC/MS/MS) and the glucose oxidase method, respectively. Treatment with pitavastatin significantly increased the peak plasma concentration (C-max) of repaglinide (P=0.003) in SLCO1B1*1b homozygotes (P=0.015) and

SLCO1B1*15 carriers (P=0.031). Treatment with pitavastatin led to a marginal increase in the area under plasma concentration-time curve from 0 h to infinity (AUC(0 ->infinity)) of repaglinide (P=0.091). There was no significant difference in pharmacokinetic parameters or hypoglycemic effects of repaglinide among SLCO1B1 genotypes in either the pitavastatin or control group. Pitavastatin increased the Cmax of the plasma concentration of repaglinide in an SLCO1B1 genotype dependent manner, but had no TPX-0005 GDC-0449 mouse apparent effect on the pharmacodynamics of repaglinide

in healthy volunteers. The p values for this statement were not reported.”
“Laparoscopic gastric greater curvature plication (LGGCP) is an emerging restrictive bariatric procedure that successfully reduces the gastric volume by plication of the gastric greater curvature. Its main advantages are the reversibility of the technique as well as the lack of foreign materials or gastrectomy. We present our results, focusing on the effectiveness and complications, and on a new modification of the original technique. One hundred and thirty-five patients underwent LGGCP between April 2008 and December 2009. A five-trocar port technique was used, and following dissection of the greater gastric curvature, single plication of the latter was performed under the guidance of a 36-Fr bougie. Modification of the technique included multiple gastric plications. One hundred and four obese women and 31 obese men (mean age of 36 years) underwent LGGCP for weight reduction. Operative time was 40-50 min, and mean hospital stay was 1.9 days (range 1-6 days). After a follow-up of 8-31 months (mean 22.59), the mean percentage of excess weight loss (%EWL) was 65.29. Subgroup analyses based on BMI values showed that %EWL was significantly higher for patients with BMI < 45 kg/mA(2) (group I) compared with patients with BMI > 45 kg/mA(2) (group II) (69.86 vs 55.49, respectively, p = 0.006).