This was significant only for the baseline BMD at the hip (p < 0.05). In the group of patients with a new non-vertebral fracture, more patients used ART than

in the group without a new non-vertebral fracture (62% versus 24%, p < 0.05). When comparing patients with and without Selleckchem ZVADFMK incident vertebral fractures, there were significantly more patients using corticosteroids (78% versus 54%) in the patients with a new vertebral fracture during follow-up (p < 0.05). Patients with new vertebral fractures had also suffered significantly more non-vertebral buy MCC950 fractures at baseline (p < 0.05), but seemed to have less vertebral fractures at baseline (p = 0.067). There was also a trend for a higher disease activity (mean CRP during follow-up and DAS-28 at baseline) in the patients with a new vertebral fracture compared to patients without a new vertebral fracture (Table 2). Table 2 Demographics and disease variables for patients with and without new vertebral and non-vertebral fractures baseline or follow-up   Vertebral fracture Non-vertebral fracture Yes (18) No (79) p Yes (16) No (86) p Age, years Mean (SD) 61 (6.5) 60 (5.8) 0.49 62 (5.0) 60 (6.1) 0.20 Disease duration, years Mean (SD) 17 (8.7) 17 (10.5)

0.95 18 (8.7) 17 (10.7) 0.70 IgM-RF positive N (%) 9 (50) 24 (30) 0.278 10 (62) 57 (67) 0.77 BMI, kg/m2 Mean (SD) 25.1 (3.8) 25.1 (4.0) 0.96 24.7 (2.9) 25.6 (5.1) S3I-201 mw 0.27 HAQ Mean (SD) 1.56 (0.35) 1.4 (0.72) 0.30 1.4 (0.75) 1.5 (0.68) 0.79 Use of corticosteroids N (%) 14 (78) 43 (54) 0.04 11 (69) 47 (54) 0.30 Use of ART during follow-up N (%) 7 (39) 24 (30) 0.49 10 (62) 21 (24) 0.002 aminophylline BMD spine, g/cm2 at baseline Mean (SD) 0.981 (0.193) 1.159 (0.516) 0.12 0.969 (0.132) 1.151 (0.585) 0.08 BMD hip, g/cm2 at baseline Mean (SD) 0.843 (0.138) 0.840 (0.165) 0.96 0.751 (0.108) 0.858 (0.159) 0.003 DAS-28 at baseline Mean (SD) 5.2 (0.7) 4.7 (1.2) 0.06 4.8 (1.2) 4.8 (1.2) 0.89 Mean ESR, mm/h Mean (SD) 22.3 (13.3) 20.1 (11.5) 0.49 21.7 (13.6) 20.8 (11.6) 0.80

Mean CRP, mg/L Mean (SD) 15.7 (8.0) 11.3 (8.1) 0.07 12.5 (6.4) 12.7 (11.7) 0.82 Vertebral fracture at baseline N (%) 1 (5) 11 (15) 0.067 5 (31) 19 (22) 0.44 Non-vertebral fracture at baseline N (%) 8 (44) 15 (19) 0.02 4 (25) 10 (11) 0.12 Of the patients who were osteopenic at baseline, seven (19%) sustained a new vertebral fracture and six (17%) a new non-vertebral fracture during follow-up. In the group of osteoporosis patients, there were seven (27%) new vertebral and seven (27%) new non-vertebral fractures during follow-up.