To ensure the stable and high output of crops, huge amount of pesticides were applied LY2874455 to control the pests, and this not only caused serious environmental pollution but also induced in a wide range

of pesticide resistance. Meanwhile by applying these chemical pesticides different varieties of pest predators were killed and the ecological balance was destroyed, thereby causing pest resurgence and a greater outbreak of secondary pests [4]. Due to this reason, many researchers have involved on alternative control methods. Botanical and microbial pesticides are having advantage over chemical pesticides by its highly effective, safe, and ecologically acceptable nature. Fortunately, bio-pesticides have been gaining increased attention and interest among those concerned with developing

environment friendly and safe integrated crop management, with compatible approaches and tactics for pest management [5]. Natural products derived from plants and microorganisms have been used for insect control YH25448 clinical trial [6]. Azadirachtin, a natural compound isolated from neem Azadirachta indica, is considered superior over other compounds since it has wide range of biological activities. Azadirachtin has been studied by many researchers and used as positive control. Bacterial and viral-based insecticides controlled different pests. Most of the pesticides from microorganisms have been isolated from entomo-pathogens and the terrestrial environment [7]. Recent studies on marine microorganisms have focused mainly on the discovery of human drugs, whereas limited information about marine microorganisms possessing insecticidal

activities has been reported. However marine environment, Non-specific serine/threonine protein kinase representing more than two thirds of our planet, is still under-explored and is considered to be a prolific resource for the isolation of less exploited microorganisms [8]. The ocean is a resource of huge drug, where more than 6000 kinds of novel chemical compounds have been isolated from marine living organisms, among which more than 1000 compounds exert biological activities, such as anti-tumour, anti-microbial and anti-virus, etc. [9]. Recently, Streptomyces sp. AP-123 producing polyketide metabolite (Figure 1) was reported by analyzing the presence of polyketide biosynthesis (PKS) biosynthetic cluster [10]. Streptomyces sp. AP-123, a Gram positive, filamentous, spore-forming antagonistic bacteria recovered from marine region at Andhra Pradesh, India. Polyketide metabolite isolated from Streptomyces sp. AP-123 acted as a growth inhibitor of Gram-positive, Gram-negative bacteria and filamentous fungi. No reports are available on the effect of polyketide metabolite against the polyphagous pest H. armigera and S. litura. The present study was aimed at assessing the antifeedant, larvicidal, pupicidal and growth inhibitory effect of polyketide metabolite isolated from Streptomyces sp. AP-123 against H. armigera and S. litura . Figure 1 Polyketide antimicrobial metabolite isolated from Streptomyces sp.