We have seen a steady rise in the number of couples seeking risk-reduction fertility treatment (Fig. 2). Risk-reduction treatment options for couples living with viral infection have been described elsewhere [11]. These

couples seek assisted conception, mainly as a preventive measure to minimize the risk of infecting their partner. The fact that half of all couples had to travel long distances from other parts of the UK to attend our clinics indicates restricted access. State funding for assisted conception treatment among couples living with blood-borne viruses should be considered a public health measure to minimize the risk of spread of the virus to partners and offspring. The last few years have seen an increase in the proportion of HIV-infected couples who received state funding for assisted conception (Fig. 3). Although this trend could be an attempt to implement National Institute AUY-922 mouse EPZ-6438 for Health and Clinical Excellence (NICE) guidelines, the increase in funding is only modest and way below NICE recommendations. Assessing the availability of state funding for assisted conception for these couples is not, however, straightforward. For instance, HIV infection is still fraught with secrecy and extreme confidentiality. The stigma associated with the condition means that most couples would rather not disclose their status even

to their GP. This may explain why only 6% of our referrals came from GPs. This tendency to secrecy means that some couples may not wish to disclose their status to the funding authorities and therefore fail to access available funds. A possible solution to this problem may be the allocation of funds to specialist centres where these couples are treated, so that couples may access the funds directly without needing

to disclose their status to a third party. In this way, funding will still be controlled by the stake-holders through the service providers, and couples will receive risk-reduction treatment with the utmost confidentiality that they desire. Although a high percentage of couples with HIV, HBV and HCV infection are voluntarily infertile and IMP dehydrogenase elect to have assisted conception with or without sperm washing to minimize the risk of viral infection of their partner and offspring, fertility screening identified a high incidence of other factors that compromise fertility. Limited access to specialist clinics equipped to cater for these couples as well as restricted funding may impact negatively on couples obtaining risk-reducing assisted reproduction treatment. This will inevitably have long-term public health implications as individuals attempt to conceive through unprotected intercourse. “
“The M184V mutation is one of the most studied mutations conferring resistance to HIV-1. This mutation is known to adversely affect viral replicative capacity as well as the efficiency of reverse transcriptase (RT) initiation and function [1,2].