Bibliography 1. Seikaly MG, et al. Pediatr Nephrol. 2009;24:1711–7. (Level 4)   2. Muller-Wiefel D, et al. Clin Nephrol. 2010;74:97–105. (Level 4)   3. Berard E, et al. Pediatr Nephrol. 2008;23:2031–8. (Level 4)   4. Vidal E, et al. Nephrol Dial Transplant. 2012;27:388–95. NVP-BSK805 (Level 4)   5. Kari JA, et al. Kidney Int. 2000;57:1681–7. (Level 4)   6. Mencarelli

F, et al. Pediatr Nephrol. 2009;24:1039–46. (Level 4)   7. Pape L, et al. Transplant Proc. 2006;38:685–7. (Level 4)   8. Fine RN, et al. Kidney Int. 2002;62:688–96. (Level 2)   9. Fine RN, et al. Pediatr Nephrol. 2010;25:739–46. (Level 4)   10. Nissel R, et al. Microvasc Res. 2009;78:246–52. (Level 4)   11. Dharnidharka VR, et al. Pediatr Transplant. 2008;12:689–95. (Level 4)   Is urological intervention for urinary tract system abnormalities in children with CKD recommended to prevent the progression of renal dysfunction? The most common condition responsible

for children with CKD is congenital anomalies of the kidney and urinary tract (CAKUT). Structural anomalies in the CAKUT spectrum are most commonly renal dysplasia and hypoplasia, often accompanied by anomalies of the extrarenal urinary tract system. Typical disorders include vesicoureteric reflux (VUR), obstructive urinary tract disorders [e.g. hydronephrosis, posterior urethral valves (PUV)], and bladder dysfunction. For all children with CKD resulting from CAKUT, it is recommended that the history of the child’s voiding FG-4592 concentration patterns be taken and that an ultrasonography be taken of the whole urinary tract. If obstruction of the urinary tract

is suggested or abnormal bladder ZD1839 nmr morphology is present, various imaging modalities, urodynamic testing, endoscopy, and other tests should be considered for further evaluation. In all patients determined to require a renal transplant, a voiding cystourethrogram (VCUG) is recommended to identify any VUR and evaluate the bladder and the urethral morphology and function. Patients with urinary system abnormalities that are confirmed as a result of these examinations require Small molecule library cell assay appropriate intervention. 1. Management of VUR in children with CKD   For VUR in children with CKD, further studies are necessary to elucidate whether prophylactic antimicrobial therapy or antireflux surgery can improve renal prognosis. VUR can be secondary to lower urinary tract abnormalities or other abnormalities, and those primary abnormalities require attention. 2. Management of lower urinary tract abnormalities in children with CKD   Among lower urinary tract abnormalities, particularly severe conditions are bladder dysfunction, PUV, and other urethral obstructive diseases.