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Oncol 2001, 28:94–104.CrossRef 41. Kerbel RS: Tumor angiogenesis: past, present and the near future. Carcinogenesis 2000, 21:505–515.CrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions The work presented here was carried out in collaboration between all authors. GG, XC, and DY conceived and designed the study. GG, HW, ZB, and JX carried out the laboratory experiments. FX, YZ, and NG prepared the nanoparticles. ZG and CG co-discussed the analyses, interpretation, and presentation. GG, HW, and XC analyzed the data and interpreted the results. GG, XC, and DY wrote the paper. All authors read and approved the final manuscript.”
“Background Graphene, which is an ideal two-dimensional system [1], has attracted a great deal of worldwide interest. Interesting effects such as Berry’s phase [2, 3] and fractional quantum Hall effect [4–6] have been observed in mechanically

exfoliated graphene flakes [1]. In addition to its extraordinary electrical properties, graphene possesses great mechanical [7], optical [8], and thermal [9] characteristics. The insulator-quantum Hall (I-QH) transition [10–13] is a MRIP fascinating physical phenomenon in the field of two-dimensional (2D) physics. In particular, a direct transition from an insulator to a high Landau-level filling factor ν > 2 QH state which is normally dubbed as the direct I-QH transition continues to attract interest [14]. The direct I-QH transition has been observed in various systems such as SiGe hole gas [14], GaAs multiple quantum well devices [15], GaAs two-dimensional electron gases (2DEGs) containing InAs quantum dots [16–18], a delta-doped GaAs quantum well with additional modulation doping [19, 20], GaN-based 2DEGs grown on sapphire [21] and on Si [22], InAs-based 2DEGs [23], and even some conventional GaAs-based 2DEGs [24], suggesting that it is a universal effect.