The most commonly utilized diagnostic serologic test is the enzyme-linked immunosorbent assay with Toxocara excretory secretory antigen. But when interpreting a serologic result, it should be kept in mind that the numerous seropositive individuals detected through screening of large populations in epidemiological surveys probably represent past rather than recent infection. A single seropositivity therefore has limited pathological significance. Immunologic testing therefore, should be accompanied by a blood eosinophil count and if possible, by determination

of serum total immunoglobulin E.4) A finding of both a peripheral eosinophilia and a positive serologic test result is indicative of active toxocariasis.5) Myocarditis in VLM may result Inhibitors,research,lifescience,medical from direct larval invasion Inhibitors,research,lifescience,medical to the myocardium and/or hypersensitivity reactions to the parasites.6) It has been suggested that there are 3 clinical stages of eosinophilic myocarditis: acute necrotizing phase, thrombotic phase and endomyocardial fibrosis phase. Loffler’s endomyocarditis

is considered to correspond to the second stage of eosinophilic endomyocardial disease. The third stage probably corresponds to restrictive myocarditis.7) Differential diagnoses include other types Inhibitors,research,lifescience,medical of myocarditis, Churg-Strauss syndrome, hypersensitivity reaction, malignant diseases, parasitic infection or hypereosinophilic syndrome. TTE finding shows diverse feature including diffuse severe hypokinesia or left ventricular focal asynergy.8) In our case, LV diastology did not showed significant dysfunction except abnormal relaxation. We think mild

decreased LV systolic function, (left ventricle ejection fraction = 48%) was the reason. Thrombus also can occur and according to its characteristics, not only Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical anticoagulation therapy but also surgical removal of the thrombus should be considered to prevent systemic embolism.9),10) Therapy is primarily based upon administration of anthelmintics. Albendazole is a benzimidazole anthelmintic and is used as AZD2014 ic50 treatment for various parasitic infections. Currently, 5 days or more use of albendazole 800 mg/day Carnitine palmitoyltransferase II or 10 mg/kg/day are recommended for treatment of T. canis infection. The mechanism of its anthelmintic action is inhibition of tubulin polymerization and microtubule-dependent glucose uptake inhibition. In this case, for the control of aggravated eosinophilia, we started administration of prednisolone. Because she didn’t have cardiac tamponade, cardiogenic shock or pulmonary edema, prednisolone was administered at 1.0 mg/kg/day.8) And as soon as we confirmed toxocara IgG positive, albendazole was added to the medication. The combination therapy with prednisolone and albendazole was effective. When a patient who has myocarditis with eosinophilia occurs, toxocara infection should be considered for possible cause.
A Vivid 7 ultrasound system (GE Vingmed Ultrasound, Horten, Norway) was used for the transthoracic echocardiographic examination.