The obtained product was purified by Afatinib cell line column chromatography (aluminum oxide, CHCl3) to this website give 10-Methyl-1,8-diazaphenothiazine (7) (0.085 g, 79 %); mp 82–83 °C 1H NMR (CDCl3) δ 3.44 (s, 3H, CH3), 6.90 (dd, J = 7.2 Hz, J = 4.9 Hz, 1H, H3), 7.18 (d, J = 5.4 Hz, 1H, H6), 7.26 (dd, J = 7.8 Hz, J = 1.8 Hz, 1H, H4), 7.90 (s, 1H, H9), 8.07 (d, J = 5.4 Hz, 1H, H7), 8.09 (dd, J = 4.9 Hz, J = 1.8 Hz, 1H, H2). 13C NMR (CDCl3) δ 32.8 (NCH3),

115.0 (C4a), 118.2 (C3), 120.8 (C6), 131.9 (C5a), 134.4 (C4), 135.2 (C9), 139.9 (C9a), 143.9 (C7), 145.8 (C2), 154.3 (C10a). EI MS m/z: 215 (M, 100), 200 (M-CH3, 80). Anal. Calcd for: C11H9N3S C 61.37, H 4.21, N 19.52. Found: C 61.22; H 4.23; N 19.41. Niraparib 10-Allyl-1,8-diazaphenothiazine (8) (0.085 g, 70 %);

an oil 1H NMR (CDCl3) δ 4.66 (m, 2H, N-CH2), 5.32 (m, 2H, =CH2), 5.96 (m, 1H, CH), 6.82 Low-density-lipoprotein receptor kinase (dd, J = 7.5 Hz, J = 5.1 Hz, 1H, H3), 7.04 (d, J = 5.0 Hz, 1H, H6), 7.18 (dd, J = 7.5 Hz, J = 1.5 Hz, 1H, H4), 7.89 (s, 1H, H9), 8.02 (m, 2H, H2, H7). 13C NMR (CDCl3) δ 47.6 (NCH2), 113.0 (C4a), 118.1 (C3), 119.2 (C6), 121.1 (CH2=), 130.2 (C5a), 131.2 (C4), 134.5 (C9), 137.9(–CH=), 138.8 (C9a), 140.2 (C7), 146.4 (C2), 151.9 (C10a). EI MS m/z: 241 (M, 50), 200 (M-CH2CHCH2, 100). Anal. Calcd for: C13H11N3S C 64.70, H 4.59, N 17.41. Found: 64.58; H 4.58; N 17.31. 10-Benzyl-1,8-diazaphenothiazine (10) (0.095 g, 65 %); an oil 1H NMR (CDCl3) δ 5.34 (s, 2H, CH2), 6.76 (dd, J = 7.2 Hz, J = 4.8 Hz, 1H, H3), 6.87 (d, J = 5.0 Hz, 1H, H6), 7.22 (dd, J = 7.2 Hz, J = 1.4 Hz, 1H, H4), 7.29 (m, 5H, C6H5), 7.81 (s, 1H, H9), 7.96 (m, 2H, H2, H7). EI MS m/z: 291 (M, 80), 200 (M-CH2C6H5, 100). Anal. Calcd for: C17H13N3S C 70.08, H 4.50, N 14.42. Found: C 70.00; H 4.52; N 14.29. 10-(4′-Nitrophenyl)-1,8-diazaphenothiazine (11) (0.120 g, 74 %); mp 171–172 °C 1H NMR (CDCl3) δ 6.88 (dd, J = 7.2 Hz, J = 5.0 Hz, 1H, H3), 6.95 (d, J = 5.0 Hz, 1H, H6), 7.21 (dd, J = 7.2 Hz, J = 1.6 Hz, 1H, H4), 7.55 (m, 2H, 2H C6H4), 7.81 (dd, J = 5.0 Hz, J = 1.6 Hz, 1H, H2), 7.96 (d, J = 5.0 Hz, 1H, H7), 8.15 (s, 1H, H9), 8.50 (m, 2H, 2H C6H4). EI MS m/z: 322 (M, 100), 276 (M-NO2, 30), 200 (M-NO2C6H4, 18). Anal. Calcd for: C16H10N4O2S C 59.62, H 3.13, N 17.38. Found: C 59.44; H 3.12; N 17.29.