RAA velocity was found to be positively correlated with LAA velocity and negatively correlated with BNP concentration. Therefore, plasma BNP concentration may serve as a determinant of LAA and RAA functions. Further study is required to determine the clinical significance of RAA.
The increased left ventricular diastolic filling pressure evolves in left ventricular (LV) diastolic dysfunction.1),2) This haemodynamic condition usually is demonstrated by the impairment of
E/A mitral inflow ratio (E/A < 1) or by the change of normal pattern of pulmonary veins' flow. The combination of early inflow velocity curve and tissue Doppler imaging #selleck inhibitor keyword# of the mitral annulus (E/E’ ratio) better estimates this condition. But, in the absence of any mitral Inhibitors,research,lifescience,medical valve derangement, LV diastolic dysfunction directly affects Left Atrial Volume (LAV). This parameter can be easily measured by two-dimensional echocardiography and indexed to the body surface area (BSA) as left atrial volume index (LAVI).3),4) Therefore, LAVI also may be used as faithful indicator of LV diastolic dysfunction.5) On the other hand, LV function can be adequately evaluated by myocardial performance index (MPI).6),7) This (also called Tei index) can be measured either with conventional Doppler method or tissue Doppler echocardiography (TDE).8)
This last method has the advantage to directly assess transmural myocardial velocities.9) In addition, TDE-MPI Inhibitors,research,lifescience,medical is more sensitive than the conventional Doppler MPI in to define LV Inhibitors,research,lifescience,medical function, especially in the presence of regional wall motion abnormality.9) In this study, we evaluated the relationship between LAVI and diastolic LV function defined with TDE-MPI in a group of hypertensive patients with LV diastolic dysfunction and ejection fraction% (EF%) Inhibitors,research,lifescience,medical > 50%. Methods Since October 2009 to February 2011, 62 hypertensive patients (43 males and 29 females) aged from 45 to 61 years (mean age = 55 ± 6 years) and without
any valvular heart diseases were examined. The leading epidemiological, metabolic and echocardiographic characteristics of controls and hypertensive patients (group II) were shown in Table 1. These were in sinus rhythm Idoxuridine and have an echocardiographic finding of left ventricular hypertrophy (LVH).10) Coronary artery disease was excluded by coronary angiography in 24 of these, and by rest and effort myocardial SPECT in the remaining 38. Cumulative anti-hypertensive treatments given in patients of group II were shown in Table 2. In accordance with the recommendations for the evaluation of LV function by echocardiography,11) the patients were diagnosed as affected by LV diastolic dysfunction, with EF% > 50% (group II).12) Table 1 Epidemiological, metabolic, and echocardiographic characteristics of controls and enrolled patients Table 2 Cumulative anti-hypertensive drugs given in 62 hypertensives Fifteen (8 males and 7 females) healthy subjects (M and F; mean age = 54 ± 3 years) was also enrolled, as controls.