As she was asymptomatic and the degree of airway stenosis was sma

As she was asymptomatic and the degree of airway stenosis was small, treatment was not required for the hemangiomas, and left upper lobectomy for lung cancer was scheduled. After induction of general anesthesia, a regular tracheal tube was inserted under fiberoptic bronchoscopy, with care taken to prevent damage to the hemangiomas. An endobronchial blocker was inserted for

one-lung ventilation. The operation was performed uneventfully, and the tracheal tube was replaced postoperatively with a laryngeal mask airway while the patient was under deep anesthesia and neuromuscular blockade. The mask was removed after confirming lack of bleeding from the hemangiomas. No hypoxia or other complications occurred during or after the operation.”
“Wood selleck chemical of fast-growing hybrid find more poplars, consisting of six 6-year-old clones in one plantation in Quebec, was impregnated with methyl methacrylate (MMA) and then polymerized by heat/catalyst method. The mechanical properties (static

bending and compressive strength) of poplar clones and its MMA-hardened wood were investigated. Significant differences were observed among clones in bending and compression strength parallel to grain. Hardening treatment has also considerably improved all strength properties except for strain at rupture in static bending. The effects of density on mechanical properties were inconsistent, especially for hardened wood. Density was not the most important factor affecting strength properties. The improved properties of MMA-hardened hybrid poplar were comparable to some commercial hardwood species. (C) 2013 Elsevier B.V. All rights reserved.”
“Background: CK10 is a heterotetramer of type I and two type II keratins. Aim: This study examines selleck inhibitor the expression pattern of cytokeratin 10 (CK10) in human testis. Materials and methods: CK10 protein expression was examined using immunofluorescense

staining methods in 30 human testicular biopsy specimens (normal spermatogenesis, maturation arrest and Sertoli cell only syndrome, 10 cases each) obtained from patients undergoing investigations for infertility. Results: In the testis showing normal spermatogenesis, CK10 was expressed in the interstitium and in the seminiferous tubules. A strong cytoplasmic expression was seen in the Leydig cells, Sertoli cells, and spermatocytes. In testes showing spermatogenic arrest, weak CK10 protein expression was observed both in the interstitium and seminiferous tubules (some primary spermatocytes). In the testes showing Sertoli cell only syndrome, negligible CK10 staining was seen both in the seminiferous tubules and in the interstitial cells of Leydig. Conclusions: To the authors’ knowledge, this is the first study indicating CK10 expression in the human testis during normal and abnormal spermatogenesis. The varied expression of CK10 in testes showing abnormal spermatogenesis suggests its possible involvement in this process.

, Staphylococcus lentus, and 2 uncultured bacterium were identifi

, Staphylococcus lentus, and 2 uncultured bacterium were identified to occupy the dominant positions in bacterial DGGE pattern, and Bacillus thermoamylovorans, Bacillus subtilis, Enterobacter spp., and Absidia corymbifera, Pichia guilliermondii, Pichia farinose were also detected from Bacillus and fungal DGGE patterns, respectively. In conclusion, some pathogenic microorganisms involving in the douchi fermentation

had been detected throughout the post-fermentation process, and the combination of culturedependent MK-4827 and -independent method was proved to be effective in profiling microbial diversity.”
“An alternative approach in determining cause, treatment, and prevention of obesity is to study those who appear resistant to the obesogenic environment. We examined appetite SBE-β-CD research buy responses in 33 obesity resistant individuals (ORI) versus 28 obesity susceptible individuals (OSI). Fingerprick blood samples to measure ghrelin, total peptide YY (PYY), leptin, glucose, and insulin along with appetite ratings were collected at baseline and 15, 30, 60, 120, and 180 min following consumption of a standardized meal. Fasting, area under

the curve (AUC), peak/nadir, and time to peak/nadir were compared. Participants completed the three factor eating questionnaire (TFEQ). No significant differences were observed for ghrelin or PYY. Higher leptin concentrations in the OSI disappeared after controlling for percent body fat (%BF). Significant differences in appetite ratings included a lower hunger nadir among OSI compared with ORI (P -

0.017). Dietary restraint (P < 0.001) and disinhibition (P < 0.001) were lower in ORI compared with OSI, with and without Selleck Z-DEVD-FMK adjustment for %BF. Given the differential body weight of the study groups, similar observed ghrelin concentrations were unexpected, perhaps indicating OSI and ORI respond differently to the same ghrelin concentration. Also ORI response to hunger appears different as they exhibit lower levels of dietary restraint and disinhibition compared with OSI. Copyright (C) 2014 Rachel C. Brown et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.”
“During poling and application in actuators, piezoelectric ceramics like lead-zirconate-titanate are exposed to static or cyclically varying electric fields, often leading to pronounced changes in the electromechanical properties. These fatigue phenomena depend on time, peak electric load, and temperature. Although this process impacts the performance of many actuator materials, its physical understanding remains elusive. This paper proposes a set of key experiments to systematically investigate the changes in the ferroelectric hysteresis, field-dependent relative permittivity, and piezoelectric coefficient after submitting the material to dc loads of varying amplitude and duration.

Treatment safety and efficacy data are mainly derived from adult

Treatment safety and efficacy data are mainly derived from adult studies and there is a lack of specific paediatric data. There are small case series selleckchem on the efficacy of adult regimens

in paediatric patients.SummaryInternational multicentre studies are necessary for the evaluation of efficacy and safety of adult-derived treatment regimens in childhood ANCA-associated vasculitides. Specific childhood outcome measurements are recently developed for research purposes and enhance clinical care.”
“Objectives: The aims of this study were to review the clinical characteristics and management of submandibular space infections and to identify the predisposing factors of life-threatening complications.

Design and methods: This was a retrospective study at a tertiary academic center. We retrieved and evaluated the records of all patients admitted to the University of Padua Otolaryngology Clinic at Treviso Regional

Hospital with the diagnosis of submandibular space infection for the period 1998-2006. The following variables were reviewed: demographic data, pathogenesis, clinical AZD7762 cost presentation, associated systemic diseases, bacteriology, imaging studies, medical and surgical treatment, and complications. A multivariate logistic regression analysis was undertaken using a forward stepwise technique.

Results: Muttivariate analysis identified four risk factors for complications. Anterior visceral space involvement (odds ratio (OR) 54.44; 95% confidence interval (CI) 5.80-511.22) and diabetes mellitus (OR 17.46; 95% CI 2.10-145.29) were the most important predictive factors in the

model. Logistic regression analysis also confirmed other comorbidities (OR 11.66; 95% CI 1.35-100.10) and bilateral submandibular swelling (OR 10.67; 95% CI 2.73-41.75) as independent predictors for life-threatening complications.

Conclusions: Airway obstruction and spread of the infection to the mediastinum are the most troublesome Selleck Caspase inhibitor complications of submandibular space infections. Therefore, the maintenance of a secure airway is paramount. Patients with cellulitis and small abscesses can respond to antibiotics alone. Surgical drainage should be performed in patients with larger abscesses, Ludwig’s angina, anterior visceral space involvement, and in those who do not respond to antibiotic treatment. Moreover, the clinical assessment in patients with comorbidities, especially diabetes mellitus, requires a high level of suspicion for potential life-threatening complications. Early surgical drainage should always be considered in these patients, even in seemingly less critical cases. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

RESULTS: Of the 250 contacts, 205 (82%) underwent repeat testing

RESULTS: Of the 250 contacts, 205 (82%) underwent repeat testing. Among 85 contacts with baseline TST-negative/QFT-negative results, TST conversion rates ranged between 7.5% and 13.8%, and QFT conversion rates ranged between 11.8% and 21.2%, depending on the definitions used. Among 109 contacts who were QFT-positive at baseline, seven (6.4%) had QFT reversions. QFT reversions

were most likely when the baseline TST was negative and QFT results were just above the diagnostic cut-off.

CONCLUSIONS: QFT conversions and reversions occurred among contacts of TB cases. Conversion rates seemed selleck compound to vary, depending on the test and definitions used for conversions. These findings need to be verified in larger studies in various settings.”
“Aim: The purpose of the present study was to compare and analyze differences in antepartal fetal heart rate (FHR) parameters during pregnancy

and pregnancy outcomes in normal fetuses and fetuses with nuchal cord (NC).”
“Automated analysis of whole mount tissue sections can provide insights into tumor subtypes and the underlying molecular basis of neoplasm. However, since tumor sections are collected from different laboratories, inherent technical and biological variations impede analysis for very large datasets such as BIX-01294 The Cancer Genome Atlas (TCGA). Our objective is to characterize tumor histopathology, through the delineation of the nuclear regions, from hematoxylin and eosin stained tissue sections. Such a representation can then be mined for intrinsic subtypes across a large dataset for prediction and molecular association. Furthermore, nuclear segmentation is formulated within a multi-reference graph framework with geodesic constraints, which enables computation of multidimensional representations, on a cell-by-cell basis, for functional enrichment and bioinformatics Selleck VX-680 analysis. Here, we present a novel method, multi-reference graph cut (MRGC), for nuclear segmentation that overcomes technical variations associated with sample

preparation by incorporating prior knowledge from manually annotated reference images and local image features. The proposed approach has been validated on manually annotated samples and then applied to a dataset of 377 Glioblastoma Multiforme (GBM) whole slide images from 146 patients. For the GBM cohort, multidimensional representation of the nuclear features and their organization have identified 1) statistically significant subtypes based on several morphometric indexes, 2) whether each subtype can be predictive or not, and 3) that the molecular correlates of predictive subtypes are consistent with the literature.

Data and intermediaries for a number of tumor types (GBM, low grade glial, and kidney renal clear carcinoma) are available at: for correlation with TCGA molecular data. The website also provides an interface for panning and zooming of whole mount tissue sections with/without overlaid segmentation results for quality control.

“Benzoyl peroxide was introduced as a basic treatment alre

“Benzoyl peroxide was introduced as a basic treatment already in acne therapy 1934. The mechanism of action is the reduction of anaerobe bacteria by strong oxidation processes. No resistancies have been ever reported. BPO is available in 2.5, 5 and 10% formulations. Its efficacy is slightly related to the strength of concentrations, AZD1208 price but the side effect profile with burning, erythema and desquamation is increasing with

concentrations. BPO 5% mostly is efficient enough to control acne of grades I to II according to the Kligman & Plewig classification. BPO my bleach clothes and hair. It is the most costeffective topical drug in acne of grades I-II.

Inflammatory acne of the papular-pustular type I-II can also be treated by topical antibiotics such as erythromycin, clindamycin, and, less frequent and today not anymore recommended tetracyclines. Mechanism of action is not alone an antibacterial but anti inflammatory effect. The efficacy and penetration of the topical antibiotics between the groups are similar. Randomized studies have shown that concentrations of 2-4% are equivalent to oral tetracycline and minocycline in mild to moderate acne. Combinatory Y-27632 concentration formulations with BPO and

with retinoids enhance the efficacy significantly. Topical antibiotics plus BPO show less bacterial resistancies as topical antibiotics alone. Antibiotics should therefore not be used as monotherapy. Moreover gram negative folliculitis may develop.

Azelaic acid is acting as an antimicrobial and can also reduce comedones. It can also be used in pregnancy and during the lactation period.”
“Machine perfusion (MP) in solid organ Ispinesib supplier transplantation has been a topic of variable importance for decades. At the dawn of organ transplantation, MP was one of the standard techniques for preservation; today’s gold standard for organ preservation for transplantation is cold storage (CS). The outcome after transplantation of solid organs has tremendously improved over

the last five decades. MP has been continuously under investigation and may be an option for organ preservation in selected cases; however, there is only little evidence from clinical trials that can be used to advocate for MP as a routine organ preservation method.

This article reviews the current knowledge on MP in the field of solid organ transplantation with special focus on findings from clinical trials.

Especially in heart and lung transplantation, MP seems to be a promising tool to improve postoperative outcome, but a general evidence-based recommendation for or against an application of MP cannot be given due to the lack of the highest level of clinical evidence. Gold standards such as CS should not be left behind without good reason.

RESULTS: The percent change in LDL cholesterol level from baselin

RESULTS: The percent change in LDL cholesterol level from baseline until study completion was statistically greater for the combination of 10 mg ezetimibe + 10 mg atorvastatin compared with increasing atorvastatin AC220 Angiogenesis inhibitor to 20 mg (-25.8% vs -15.1%; P < 0.0001). A similar result was observed for ezetimibe + atorvastatin compared with switching to 2.5 mgt rosuvastatin (-25.8% vs 0.8%; P <

0.0001). The proportion of patients who reached the target LDL cholesterol value with the combination of ezetimibe + atorvastatin was significantly higher than increasing atorvastatin and switching to rosuvastatin (78.7%, 41.3%, and 3.1%, respectively). Although 5 serious adverse experiences bearing no relation to the study medications were reported, there were no adverse reactions.

CONCLUSIONS: The combination of 10 mg ezetimibe +10 mg atorvastatin was more effective than increasing atorvastatin to 20 mg or switching to 2.5 mg rosuvastatin in patients with hypercholesterolemia whose LDL cholesterol levels had not reached the recommended target value with 10 mg atorvastatin monotherapy for 4 weeks. Ezetimibe coadministration with atorvastatin was well tolerated. identifier: NCT 00871351. (Curr Ther Res Clin Exp. 2012;73:16-40) (c) 2012 Elsevier

HS Journals, Inc. All rights reserved.”
“Objective: The objective of our case report is to increase the awareness of neutropenia as a rare but potentially serious adverse outcome of commonly used dopamine agonists for the treatment of prolactinomas.

Methods: This report reviews the clinical history, diagnosis, investigations, and drug treatment of our patient.

Results: Neutropenia was recurrent after changing to various different dopamine agonists necessitating surgical treatment of a prolactinoma.

Conclusion: This case serves a reminder of this adverse drug reaction. Considering the significant impact and potentially a life threatening outcome, we advocate routine monitoring of full blood count prior Rigosertib chemical structure to and during the treatment with dopamine

“BACKGROUND: Supercritical antisolvent (SAS) micronisation of synthetic trans-beta-carotene was studied using tetrahydrofuran (THF) as solvent and supercritical carbon dioxide (CO2) as antisolvent, with the objective of increasing its bioavailability and facilitating its dispersion in oil and emulsion formulations as a result of its smaller particle size. The micronised powder was analysed by scanning electron microscopy and high-performance liquid chromatography. Micronisation experiments were performed in order to evaluate the effects of temperature (308.15-333.15 K), pressure (6.5-13 MPa) and concentration of the liquid solution (6-9 g L-1). The effect of the supercritical CO2/THF flow ratio in the range between 4 and 44 (on a mass basis) was also analysed.

The appearance of nosocomial infection, localisation, and the cau

The appearance of nosocomial infection, localisation, and the causative agent, if isolated, were included; demographic and clinical analytical variables, duration and type of antibiotic prophylaxis, and duration of other invasive devices were also included. Standard analysis and multivariable logistical regression were performed. 194 patients click here were included in the study. The median duration of antibiotic prophylaxis was 72 h (range 24 to 176), with the most-used prophylaxis regimen being second-generation cephalosporins plus aminoglycosides.

The incidence of nosocomial infection, mainly bacteraemia, was 11.9%. The type of antibiotic therapy used for prophylaxis did not affect the incidence of infection. In the multivariable logistical regression, only prolongation of antibiotic prophylaxis > 48 h, central venous access

maintenance Selleck GSI-IX time, and intubation increased the infection rate. The suspension of antibiotic prophylaxis in the 48 h after surgery in pediatric patients undergoing heart surgery does not increase the incidence of nosocomial infection. According to our results, prolongation of prophylaxis > 48 h increases the infection rate.”
“Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder characterized by progressive cerebellar ataxia associated with macular degeneration that leads, in the majority of patients, to loss of autonomy and blindness. The cause of the disease has been identified as (CAG) SIS3 molecular weight (n) repeat expansion in the coding sequence of the ATXN7 gene on chromosome 3p21.1. SCA7 is one of the least common genetically verified autosomal dominant cerebellar ataxias found worldwide; however, we previously identified the Mexican population showing high prevalence of SCA7, suggesting the occurrence of a common founder effect. In this study, haplotype analysis using four SCA7 gene-linked markers revealed that all 72 SCA7 carriers studied share a common haplotype, A-254-82-98, for the intragenic marker 3145G/A and centromeric markers D3S1287, D3S1228, and D3S3635, respectively.

This multiloci combination is uncommon in healthy relatives and Mexican general population, suggesting that a single ancestral mutation is responsible for all SCA7 cases in this population. Furthermore, genotyping using 17 short tandem repeat markers from the non-recombining region of the Y chromosome and further phylogenetic relationship analysis revealed that Mexican patients possess the Western European ancestry, which might trace the SCA7 ancestral mutation to that world region.”
“Objective: The purpose is to report our 10-year experience with surgical management of large or symptomatic adrenal myelolipoma. Patients and Methods: Patients receiving surgical treatment for adrenal myelolipoma between December 2001 and September 2011 in our institution were retrospectively reviewed. Patients were divided into two groups: open surgery and laparoscopic surgery.

Conclusion: In this cohort of older adults with

Conclusion: In this cohort of older adults with check details limited egg intake, there was no association between egg consumption or dietary cholesterol and increased risk of incident T2D. Am J Clin Nutr 2010; 92: 422-7.”
“In this report, we grow MnCr2O4 (124) films, and Mn2CrO4 (214) films, for comparison, on MgO and SrTiO3 (STO) substrates by oxygen-plasma-assisted molecular beam epitaxy and also carry out the measurements of the magnetization as a function of temperature (5-200 K) and external field (0-5 T) of these films. The results of magnetization versus temperature further show that ferrimagnetic transition (T-c) occurs at 44 K for 214 films grown on both MgO and STO. The T-c of 124 films raises to 45

K but is only observed for the film selleck chemical grown on STO. No or very weak magnetization is observed for the 124 films grown on MgO(001). The vanishing of the magnetization of the 124 films grown on MgO is attributed to the instability of spinel structure for Cr-rich films. Magnetic hysteresis curves of the films further show the magnetization saturation (M-s) of 124 is <1/2 bohr magneton, which is noticeably smaller

than the bulk M-s similar to 1 bohr magneton. The reduction of M-s in these chromites films may result from the cation distribution in that Cr cations distribute in both A and B sites, which is different from the bulk materials. The distribution of Cr cations in both A and B is attributed to the low temperature growth and similar results have been found in previous growth of various ferrite films. (C) 2011 American Institute of Physics. [doi:10.1063/1.3545802]“
“A series of poly(vinyl alcohol)

(PVA)-based single-layer organic polymeric membranes were prepared via the crosslinking of PVA with different amounts of formaldehyde. Meanwhile, for comparison, both a three-layer organic polymeric membrane and a hybrid composite membrane were also prepared by the layer-upon-layer method. Their thermal stability and tensile properties were investigated to examine the effect of crosslinking on the membrane performances. Thermogravimetric analysis and differential scanning calorimetry thermal analyses showed that the thermal degradation Etomoxir temperature of the single-layer crosslinked membrane C reached up to 325 degrees C. Tensile testing indicated that the three-layer organic polymeric membrane E had excellent tensile strength among these single-layer and three-layer membranes. The swelling properties revealed that the swelling degree value of these membranes decreased with an increase in methanol concentration; this suggests that they were not easily swollen by the methanol solution, which is meaningful for the separation of organic mixtures. Field emission scanning electron microscopy images exhibited that the crosslinking of functional groups impacted their structures and confirmed that their mechanical properties were related to their structures.

Results: Ten patients received MMF for >6 months MMF

Results: Ten patients received MMF for >6 months. MMF PR-171 supplier was introduced due to side effects (5/10 patients) and due to an inadequate response to prior therapy (5/10 patients). Median duration of treatment with MMF was 31

months (range 8-66). Therapeutic MMF plasma trough levels of 1-3 mg/l were reached with daily doses of 1,722 +/- 440 mg MMF. Daily corticosteroid dose could be significantly reduced from 14.3 +/- 13.3 to 6.5 +/- 2.3 mg prednisolone during treatment. During follow-up, pulmonary function, symptoms and radiological signs improved in 4 patients, while 6 patients remained stable. Median change in FVC was +8.5 % (range -2 to 16). No severe adverse events that were related to combined immunosuppressive therapy occurred. Conclusion: This

study indicates that the addition of MMF to corticosteroids is a viable and safe treatment option in CPS. MMF allows a significant reduction of maintenance Small molecule library mouse corticosteroids to levels < 10 mg/day while preserving a stable or improved clinical condition. Copyright (C) 2012 S. Karger AG, Basel”
“Objectives: Alcohol screening and brief interventions in medical settings can significantly reduce alcohol use. Corresponding data for illicit drug use is sparse. A Federally funded screening, brief interventions. referral to treatment (SBIRT) service program, the largest of its kind to date, was initiated by the Substance Abuse and Mental Health Services Administration (SAMHSA) in a wide variety of medical settings. We compared illicit drug use at intake P505-15 and 6 months after drug screening and interventions were administered.

Design: SBIRT services were implemented in a range of medical settings across six states. A diverse patient population (Alaska Natives, American Indians, African-Americans. Caucasians, Hispanics), was screened and offered score-based progressive levels of intervention (brief intervention, brief treatment, referral to specialty treatment). In this secondary analysis of the SBIRT service program, drug use data was compared at intake and at a 6-month follow-up, in a sample of a randomly selected population (10%) that screened

positive at baseline.

Results: Of 459,599 patients screened, 22.7% screened positive for a spectrum of use (risky/problematic, abuse/addiction). The majority were recommended for a brief intervention (15.9%), with a smaller percentage recommended for brief treatment (3.2%) or referral to specialty treatment (3.7%). Among those reporting baseline illicit drug use, rates of drug use at 6-month follow-up (4 of 6 sites), were 67.7% lower (p < 0.001) and heavy alcohol use was 38.6% lower (p < 0.001), with comparable findings across sites, gender, race/ethnic, age subgroups. Among persons recommended for brief treatment or referral to specialty treatment, self-reported improvements in general health (p < 0.001), mental health (p < 0.001), employment (p < 0.

Therefore, we recommend a more targeted assay,

Therefore, we recommend a more targeted assay, JNK-IN-8 mw such

as e. g. QF-PCR, as a replacement of the STC and to provide parents the autonomy to choose between karyotyping and QF-PCR.”
“BACKGROUND Lead is one of the frequent contaminants of industrial wastewater. Since it has been shown that aquatic plants can be used for the removal of heavy metals, herein Pb(II) biosorption by Myriophyllum spicatum and its compost were investigated. Effects of pH, ionic strength and contact time were analyzed using a batch experiment. Biomasses were characterized chemically and by Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction techniques. RESULTS The adsorption process of both biosorbents followed a pseudo-second-order kinetic model. Compost exhibits better Pb(II) removal from solution (71%) compared with the plant (61%). Lead binding capacities for M. spicatum and its compost were 0.234 mmol g(-1) and 0.287 mmol g(-1) at pH 5.0, respectively. Lead binding takes place mainly through an ion exchange mechanism, but chemisorption via identified functional groups cannot be neglected. The Langmuir, Freundlich and Sips adsorption models for compost

were applied. The Sips isotherm model gave the best fit with the equilibrium experimental data. The sorption process by compost was endothermic and spontaneous. CONCLUSION Aquatic weed compost as a low cost biosorbent with high biosorption capacity can potentially be used for the removal of lead from wastewaters. (c) 2013 Society of Chemical Industry”
“Effects buy GSK J4 of 1 MeV electron-irradiation at room temperature on the electrical

properties of AlGaN/GaN heterostructures, including leakage currents, threshold voltages, and electron traps, have been investigated using Schottky barrier diodes (SBDs) fabricated on the AlGaN. The SBDs, before and after the irradiation with a dose of 5 x 10(15) cm(-2), were characterized by temperature dependent current-voltage and capacitance-voltage measurements and deep level transient spectroscopy. It is PLX3397 mw found that the irradiation causes (i) significant increase in leakage currents, dominated by tunneling conduction, at both reverse and low-forward biases; (ii) a clear negative shift in threshold voltage in the pinch-off region; and (iii) creation of traps A(e)(similar to 1.1 eV) or A(2)(1.2 eV) and E(e)(0.09 eV) in the GaN buffer and AlGaN regions. The irradiation-induced traps can be used to account for the increase in leakage currents and shift in threshold voltage. However, as compared to traps A(2)(1.2 eV) and E(0.13 eV) induced in thick GaN layers by electron-irradiation, the irradiation-induced traps in the AlGaN/GaN heterostructures show some changes in activation energy and electron capture behavior. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3151952]“
“Background: The majority of Marfan syndrome (MFS) cases is caused by mutations in the fibrillin-1 gene (FBN1), mapped to chromosome 15q21.1.